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  1. Article

    Open Access

    Establishment of a transgenic mouse to model ETV7 expressing human tumors

    The ETS transcription factor ETV7 has been characterized as a hematopoietic oncoprotein, which requires cooperating mutations for its leukemogenic activity. Although the ETV7 gene is highly conserved among verteb...

    Masashi Numata, R. I. Klein Geltink, Gerard C. Grosveld in Transgenic Research (2019)

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    Article

    γ-secretase inhibitors: Notch so bad

    γ-secretase inhibitors inhibit Notch, a transmembrane receptor that drives many cases of T cell acute lymphoblastic leukemia—but there are safety concerns with such drugs. Combining these inhibitors with gluco...

    Gerard C Grosveld in Nature Medicine (2009)

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    Article

    The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype

    Stem cells from bone marrow, skeletal muscle and possibly other tissues can be identified by the 'side-population' (SP) phenotype. Although it has been assumed that expression of ABC transporters is responsibl...

    Sheng Zhou, John D. Schuetz, Kevin D. Bunting, Anne-Marie Colapietro… in Nature Medicine (2001)