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  1. No Access

    Article

    γ-secretase inhibitors: Notch so bad

    γ-secretase inhibitors inhibit Notch, a transmembrane receptor that drives many cases of T cell acute lymphoblastic leukemia—but there are safety concerns with such drugs. Combining these inhibitors with gluco...

    Gerard C Grosveld in Nature Medicine (2009)

  2. No Access

    Article

    The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype

    Stem cells from bone marrow, skeletal muscle and possibly other tissues can be identified by the 'side-population' (SP) phenotype. Although it has been assumed that expression of ABC transporters is responsibl...

    Sheng Zhou, John D. Schuetz, Kevin D. Bunting, Anne-Marie Colapietro… in Nature Medicine (2001)