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  1. No Access

    Article

    Schizophrenia: signals from the other side

    Animal models of schizophrenia are incomplete, and human brain tissue has been difficult to study. Results from postmortem human tissue begin to overcome these hurdles and find a role for modulation of NMDA ty...

    Gerald D Fischbach in Nature Medicine (2006)

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    Article

    Calcium-dependent, slow desensitization distinguishes different types of glutamate receptors

    1. L-Glutamate, the most likely transmitter of rapid excitatory synaptic interactions in the brain and spinal co...

    Charles F. Zorumski, Jay Yang, Gerald D. Fischbach in Cellular and Molecular Neurobiology (1989)

  3. No Access

    Article

    Differential activation of myotube nuclei following exposure to an acetylcholine receptor-inducing factor

    A glycoprotein purified from chick brain, of relative molecular mass 42,000, increases the rate of appearance of acetylcholine receptors (AChRs) on the surface of chick myotubes1. RNase protection assays have sho...

    David A. Harris, Douglas L. Falls, Gerald D. Fischbach in Nature (1989)

  4. No Access

    Chapter

    The Accumulation of Acetylcholine Receptors at Nerve—Muscle Synapses in Culture

    We are studying the formation of synapses between embryonic chick ciliary-ganglion neurons and muscle fibers maintained in cell culture. Our assumption is that certain rules that govern synapse formation can b...

    Gerald D. Fischbach, Lorna W. Role… in Cellular and Molecular Biology of Neuronal… (1984)

  5. No Access

    Article

    Regulation of acetylcholinesterase appearance at neuromuscular junctions in vitro

    The appearance of acetylcholinesterase (AChE) at newly formed nerve–muscle synapses depends on synaptic transmission. Synapses form when cultures are grown in the presence of acetylcholine receptor antagonists...

    Lee L. Rubin, Stephen M. Schuetze, Cheryl L. Weill, Gerald D. Fischbach in Nature (1980)

  6. No Access

    Chapter

    Effect of enkephalin on sensory neurons in cell culture: inhibition of substance P release and reduction of inward calcium currents

    The two peptides substance P and β-enkephalin are associated anatomically in many areas of the nervous system that are related to pain and analgesia. For example, β-enkephalin is present in interneurons in the...

    Anne W. Mudge, Susan E. Leeman, Gerald D. Fischbach in Endorphins in Mental Health Research (1979)

  7. No Access

    Article

    Neurotransmitters decrease the calcium component of sensory neurone action potentials

    RELEASE of neurotransmitters from presynaptic axon terminals requires the influx of Ca2+ ions during the nerve terminal action potential1. Action potentials recorded in some neurone cell bodies exhibit a relative...

    KATHLEEN DUNLAP, GERALD D. FISCHBACH in Nature (1978)

  8. No Access

    Article

    A discontinuous relationship between the acetylcholine-activated channel conductance and temperature

    SINCE the introduction of acetylcholine (ACh) ‘noise’ analysis1,2, it has been shown that several manipulations affect ACh-receptor molecular events3–5. The ACh receptor is an integral membrane protein and is the...

    YORAM LASS, GERALD D. FISCHBACH in Nature (1976)