7 Result(s)
within
George Kassiotis
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessAntibodies against endogenous retroviruses promote lung cancer immunotherapy
B cells are frequently found in the margins of solid tumours as organized follicles in ectopic lymphoid organs called tertiary lymphoid structures (TLS)1,2. Although TLS have been found to correlate with improved...
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Article
Open AccessADAR1 averts fatal type I interferon induction by ZBP1
Mutations of the ADAR1 gene encoding an RNA deaminase cause severe diseases associated with chronic activation of type I interferon (IFN) responses, including Aicardi–Goutières syndrome and bilateral striatal nec...
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Article
Publisher Correction: Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation
The biological function of Z-DNA and Z-RNA, nucleic acid structures with a left-handed double helix, is poorly understood1–3. Z-DNA-binding protein 1 (ZBP1; also known as DAI or DLM-1) is a nucleic acid sensor th...
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Article
Open AccessTetherin/BST-2 promotes dendritic cell activation and function during acute retrovirus infection
Tetherin/BST-2 is a host restriction factor that inhibits retrovirus release from infected cells in vitro by tethering nascent virions to the plasma membrane. However, contradictory data exists on whether Tetheri...
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Article
Open AccessStepwise B-cell-dependent expansion of T helper clonotypes diversifies the T-cell response
Antigen receptor diversity underpins adaptive immunity by providing the ground for clonal selection of lymphocytes with the appropriate antigen reactivity. Current models attribute T cell clonal selection duri...
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Article
Resurrection of endogenous retroviruses in antibody-deficient mice
Novel pathogenic infectious retroviruses, generated by recombination between replication-defective endogenous retroviruses in the absence of a functional antibody response, are identified; these recombinant re...
