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Article
Open AccessFast X-ray ptychography: towards nanoscale imaging of large volume of brain
X-ray ptychography, a scanning coherent diffraction imaging technique, is one of the most used techniques at synchrotron facilities for high resolution imaging, with applications spanning from life science to ...
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Article
Open AccessFilter exchange imaging with crusher gradient modelling detects increased blood–brain barrier water permeability in response to mild lung infection
Blood–brain barrier (BBB) dysfunction occurs in many brain diseases, and there is increasing evidence to suggest that it is an early process in dementia which may be exacerbated by peripheral infection. Filter...
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Chapter
Co-electrohydrodynamic Forming of Biomimetic Polymer Materials for Diffusion Magnetic Resonance Imaging
Magnetic resonance imaging (MRI) is routinely used as a medical imaging modality in the disease detection, monitoring, and therapy response assessment in neurology and cancer. An attractive feature of MRI is i...
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Article
Open AccessDynamic contrast-enhanced MRI of synovitis in knee osteoarthritis: repeatability, discrimination and sensitivity to change in a prospective experimental study
Evaluate test-retest repeatability, ability to discriminate between osteoarthritic and healthy participants, and sensitivity to change over 6 months, of dynamic contrast-enhanced magnetic resonance imaging (DC...
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Article
Open AccessEffect of oxaliplatin plus 5-fluorouracil or capecitabine on circulating and imaging biomarkers in patients with metastatic colorectal cancer: a prospective biomarker study
Patients with metastatic colorectal cancer are treated with cytotoxic chemotherapy supplemented by molecularly targeted therapies. There is a critical need to define biomarkers that can optimise the use of the...
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Article
Open AccessExtracellular resistance is sensitive to tissue sodium status; implications for bioimpedance-derived fluid volume parameters in chronic kidney disease
Multifrequency bioimpedance spectroscopy (BIS) is an established method for assessing fluid status in chronic kidney disease (CKD). However, the technique is lacking in predictive value and accuracy. BIS algor...
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Article
Open AccessPlasma Tie2 is a tumor vascular response biomarker for VEGF inhibitors in metastatic colorectal cancer
Oncological use of anti-angiogenic VEGF inhibitors has been limited by the lack of informative biomarkers. Previously we reported circulating Tie2 as a vascular response biomarker for bevacizumab-treated ovari...
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Article
Open AccessImaging biomarker roadmap for cancer studies
Imaging biomarkers (IBs) are used extensively in drug development and cancer research, but important differences exist between IBs and biospecimen-derived biomarkers. A tailored 'roadmap' is required for the d...
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Reference Work Entry In depth
Dynamic Contrast-Enhanced Magnetic Resonance Imaging
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Living Reference Work Entry In depth
Dynamic Contrast-Enhanced Magnetic Resonance Imaging
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Chapter
Co-electrospun Brain Mimetic Hollow Microfibres Fibres for Diffusion Magnetic Resonance Imaging
Diffusion magnetic resonance imaging (dMRI) provides a non-invasive tool to explore biological tissues, including brain with its highly organised hierarchical fibrous structures. An MR phantom is a test object...
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Article
A phase 1 trial of intravenous 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) in patients with advanced solid tumours
4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) is a water-soluble mitochondrial toxin that binds to adenine nucleotide translocase in the inner mitochondrial membrane, thereby targeting cell proliferat...
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Article
Dynamic contrast-enhanced MRI in clinical trials of antivascular therapies
Should dynamic contrast-enhanced (DCE)-MRI be used in the assessment of drug-development of antivascular agents? In this Review, O'connor et al. discuss whether data from DCE-MRI are reliable and reproducible bio...
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Reference Work Entry In depth
Dynamic Contrast-Enhanced Magnetic Resonance Imaging
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Article
Imaging angiogenesis of genitourinary tumors
The targeting of angiogenesis is a growing area of cancer therapy.In vivo imaging techniques allow the noninvasive evaluation of changes in tumor vasculature in response to antiangiogenic agents. Zee et al. prov...
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Article
Open AccessTumour enhancing fraction (EnF) in glioma: relationship to tumour grade
The aim of this research was to determine whether the proportion of a tumour that enhances (enhancing fraction, EnF) and changes in EnF with enhancement threshold differ between low and high grade glioma. Fort...
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Reference Work Entry In depth
Dynamic Contrast-Enhanced Magnetic Resonance Imaging
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Chapter and Conference Paper
Tracer Kinetic Model-Driven Registration for Dynamic Contrast Enhanced MRI Time Series
Motion during time-series data acquisition causes model-fitting errors in quantitative dynamic contrast-enhanced (DCE) MRI studies. Motion correction techniques using conventional registration cost functions m...
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Chapter and Conference Paper
Probabilistic Monte Carlo Based Map** of Cerebral Connections Utilising Whole-Brain Crossing Fibre Information
A methodology is presented for estimation of a probability density function of cerebral fibre orientations when one or two fibres are present in a voxel. All data are acquired on a clinical MR scanner, using w...
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Article
The relationship between lesion and normal appearing brain tissue abnormalities in early relapsing remitting multiple sclerosis
Background In multiple sclerosis (MS), pathological changes have been found both in macroscopic lesions and normal appearing tissue. Magnetisation transfer ratio (MTR) and T1 relaxation time are abnormal in norm...
