3,134 Result(s)
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Article
Adenylate kinase fromRhodospirillum rubrum
A partial purification and some properties of adenylate kinase from the photosynthetic bacteriumRhodospirillum rubrum are described.
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Erratum
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Interaction of viral proteins with host cell death machinery
In recent years, intense research has been directed towards understanding molecular mechanisms involved in viral pathogenesis. It is now known that many viruses manipulate host defense mechanisms to prevent ap...
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Bacterial death induced by expression of the intracellular portion of human Fas
In attempting to produce the intracellular portion of human Fas (IC175–319) as a GST-fusion protein we found that expression of GST-IC175–319, but not GST alone or GST-IC231–298 (containing the Fas death domain),...
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Soluble Fas gene therapy protects against Fas-mediated apoptosis of hepatocytes but not the lethal effects of Fas-induced TNF-α production by Kupffer cells
The elevation of soluble Fas (sFas) in the sera of patients with liver disease suggests a role for sFas in the disease process; whether it is protective or not is controversial. To determine the effects of sFa...
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Induction of acetylcholinesterase expression during apoptosis in various cell types
Acetylcholinesterase (AChE) plays a key role in terminating neurotransmission at cholinergic synapses. AChE is also found in tissues devoid of cholinergic responses, indicating potential functions beyond neuro...
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Regulation of p53 responses by post-translational modifications
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Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK Complex
Caspase-11 is a key regulator of proinflammatory cytokine IL-1β maturation and pathological apoptosis. Caspase-11 is not expressed in most tissues under normal condition, but highly inducible upon pathological st...
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Decoy receptor 3 (DcR3) induces osteoclast formation from monocyte/macrophage lineage precursor cells
Recent evidence indicates that the decoy receptor 3 (DcR3) of the TNF receptor superfamily, which initially though prevents cytokine responses of FasL, LIGHT and TL1A by binding and neutralization, can modulat...
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EDAG regulates the proliferation and differentiation of hematopoietic cells and resists cell apoptosis through the activation of nuclear factor-κB
Erythroid differentiation-associated gene (EDAG) is considered to be a human hematopoiesis-specific gene. Here, we reported that downregulation of EDAG protein in K562 cells resulted in inhibition of growth an...
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Galectin-1 induces nuclear translocation of endonuclease G in caspase- and cytochrome c-independent T cell death
Galectin-1, a mammalian lectin expressed in many tissues, induces death of diverse cell types, including lymphocytes and tumor cells. The galectin-1 T cell death pathway is novel and distinct from other death ...
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Open AccessCharacterization of TRZ1, a yeast homolog of the human candidate prostate cancer susceptibility gene ELAC2 encoding tRNase Z
In humans, mutation of ELAC2 is associated with an increased risk of prostate cancer. ELAC2 has been shown to have tRNase Z activity and is associated with the γ-tubulin complex.
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Open AccessNuclear distribution and chromatin association of DNA polymerase α-primase is affected by TEV protease cleavage of Cdc23 (Mcm10) in fission yeast
Cdc23/Mcm10 is required for the initiation and elongation steps of DNA replication but its biochemical function is unclear. Here, we probe its function using a novel approach in fission yeast, involving Cdc23 ...
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Inhibition of glycogen synthase kinase 3β suppresses coxsackievirus-induced cytopathic effect and apoptosis via stabilization of β-catenin
Coxsackievirus B3 (CVB3), a common human pathogen for viral myocarditis, induces a direct cytopathic effect (CPE) and apoptosis on infected cells. To elucidate the mechanisms that contribute to these processes...
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Expression of a synthetic cholera toxin B subunit in tobacco using ubiquitin promoter and bar gene as a selectable marker
A protocol has been developed to produce a cholera toxin B subunit (CTB) in tobacco tolerant to the herbicide phosphinothricin (PPT) by means of in vitro selection. The synthetic CTB subunit gene was altered t...
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Human β-defensins
The last decade led to the discovery and characterization of several human β-defensins. Analysis of genomic information indicates that the number of β-defensin-like molecules encoded by the human genome may nu...
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Open AccessSerum repressing efflux pump CDR1 in Candida albicans
In the past decades, the prevalence of candidemia has increased significantly and drug resistance has also become a pressing problem. Overexpression of CDR1, an efflux pump, has been proposed as a major mechanism...
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BCL2 family in DNA damage and cell cycle control
Individual BCL2 family members couple apoptosis regulation and cell cycle control in unique ways. Antiapoptotic BCL2 and BCL-xL are antiproliferative by facilitating G0. BAX is proapoptotic and accelerates S-phas...
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M and N proteins of SARS coronavirus induce apoptosis in HPF cells
Background: SARS-associated coronavirus (SARS-CoV) induced cell apoptosis and its structural proteins may play a role in this process. Objectives: To determine whether the structural proteins M a...
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Erk is involved in the differentiation induced by diallyl disulfide in the human gastric cancer cell line MGC803
Diallyl disulfide (DADS) is a major constituent of garlic. Previously, we found that DADS both inhibited proliferation in human gastric cancer cells in vitro and in vivo, and induced G2/M arrest. In this study, w...