591 Result(s)

Article

Interaction of viral proteins with host cell death machinery

In recent years, intense research has been directed towards understanding molecular mechanisms involved in viral pathogenesis. It is now known that many viruses manipulate host defense mechanisms to prevent ap...

David J Granville, Chris M Carthy, Decheng Yang… in Cell Death & Differentiation (1998)

Article

Bacterial death induced by expression of the intracellular portion of human Fas

In attempting to produce the intracellular portion of human Fas (IC_175–319) as a GST-fusion protein we found that expression of GST-IC_175–319, but not GST alone or GST-IC_231–298 (containing the Fas death domain),...

Yili Yang, June S Hong, Astrid Eder, Jonathan D Ashwell in Cell Death & Differentiation (1999)

Article

Soluble Fas gene therapy protects against Fas-mediated apoptosis of hepatocytes but not the lethal effects of Fas-induced TNF-α production by Kupffer cells

The elevation of soluble Fas (sFas) in the sera of patients with liver disease suggests a role for sFas in the disease process; whether it is protective or not is controversial. To determine the effects of sFa...

Y Matsuki, L Li, H-C Hsu, P A Yang, R Zheng… in Cell Death & Differentiation (2002)

Article

Induction of acetylcholinesterase expression during apoptosis in various cell types

Acetylcholinesterase (AChE) plays a key role in terminating neurotransmission at cholinergic synapses. AChE is also found in tissues devoid of cholinergic responses, indicating potential functions beyond neuro...

X J Zhang, L Yang, Q Zhao, J P Caen, H Y He, Q H **… in Cell Death & Differentiation (2002)

Article

Regulation of p53 responses by post-translational modifications

Yang Xu in Cell Death & Differentiation (2003)

Article

Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK Complex

Caspase-11 is a key regulator of proinflammatory cytokine IL-1β maturation and pathological apoptosis. Caspase-11 is not expressed in most tissues under normal condition, but highly inducible upon pathological st...

M Kobori, Z Yang, D Gong, V Heissmeyer, H Zhu, Y-K Jung… in Cell Death & Differentiation (2004)

Article

Decoy receptor 3 (DcR3) induces osteoclast formation from monocyte/macrophage lineage precursor cells

Recent evidence indicates that the decoy receptor 3 (DcR3) of the TNF receptor superfamily, which initially though prevents cytokine responses of FasL, LIGHT and TL1A by binding and neutralization, can modulat...

C R Yang, J H Wang, S L Hsieh, S M Wang, T L Hsu, W W Lin in Cell Death & Differentiation (2004)

Article

EDAG regulates the proliferation and differentiation of hematopoietic cells and resists cell apoptosis through the activation of nuclear factor-κB

Erythroid differentiation-associated gene (EDAG) is considered to be a human hematopoiesis-specific gene. Here, we reported that downregulation of EDAG protein in K562 cells resulted in inhibition of growth an...

C Y Li, Y Q Zhan, C W Xu, W X Xu, S Y Wang, J Lv, Y Zhou… in Cell Death & Differentiation (2004)

Article

Galectin-1 induces nuclear translocation of endonuclease G in caspase- and cytochrome c-independent T cell death

Galectin-1, a mammalian lectin expressed in many tissues, induces death of diverse cell types, including lymphocytes and tumor cells. The galectin-1 T cell death pathway is novel and distinct from other death ...

H P Hahn, M Pang, J He, J D Hernandez, R-Y Yang, L Y Li… in Cell Death & Differentiation (2004)

Article

Inhibition of glycogen synthase kinase 3β suppresses coxsackievirus-induced cytopathic effect and apoptosis via stabilization of β-catenin

Coxsackievirus B3 (CVB3), a common human pathogen for viral myocarditis, induces a direct cytopathic effect (CPE) and apoptosis on infected cells. To elucidate the mechanisms that contribute to these processes...

J Yuan, J Zhang, B W Wong, X Si, J Wong, D Yang, H Luo in Cell Death & Differentiation (2005)

Article

BCL2 family in DNA damage and cell cycle control

Individual BCL2 family members couple apoptosis regulation and cell cycle control in unique ways. Antiapoptotic BCL2 and BCL-x_L are antiproliferative by facilitating G0. BAX is proapoptotic and accelerates S-phas...

S Zinkel, A Gross, E Yang in Cell Death & Differentiation (2006)

Article

Activation of the transient receptor potential M2 channel and poly(ADP-ribose) polymerase is involved in oxidative stress-induced cardiomyocyte death

Overproduction of reactive oxygen species is one of the major causes of cell death in ischemic–reperfusion (I/R) injury. In I/R animal models, electron microscopy (EM) has shown mixed apoptotic and necrotic ch...

K-T Yang, W-L Chang, P-C Yang, C-L Chien, M-S Lai, M-J Su… in Cell Death & Differentiation (2006)

Article

Homotypic FADD interactions through a conserved RXDLL motif are required for death receptor-induced apoptosis

Death receptors in the TNF receptor superfamily signal for apoptosis via the ordered recruitment of FADD and caspase-8 to a death-inducing signaling complex (DISC). However, the nature of the protein–protein i...

J R Muppidi, A A Lobito, M Ramaswamy, J K Yang, L Wang… in Cell Death & Differentiation (2006)

Article

A novel cellular survival factor – the B2 subunit of vacuolar H⁺-ATPase inhibits apoptosis

The ubiquitous vacuolar H⁺-ATPase, a multisubunit proton pump, is essential for intraorganellar acidification. Disruption of its function leads to disturbances of organelle function and cell death. Here, we repor...

G Li, Q Yang, S Krishnan, E A Alexander, S C Borkan… in Cell Death & Differentiation (2006)

Article

E2F6 negatively regulates ultraviolet-induced apoptosis via modulation of BRCA1

E2F6 is believed to repress E2F-responsive genes and therefore plays an important role in cell-cycle regulation. However, the role of E2F6 in the control of apoptosis remains unknown. We show here that the exp...

W-W Yang, Z-H Wang, Y Zhu, H-T Yang in Cell Death & Differentiation (2007)

Article

Antagonism of p66shc by melanoma inhibitory activity

The p66shc protein governs oxidant stress and mammalian lifespan. Here, we identify melanoma inhibitory activity (MIA), a protein secreted by melanoma cells, as a novel binding partner and antagonist of p66shc...

K Kasuno, A Naqvi, J DeRicco, T Yamamori, L Santhanam… in Cell Death & Differentiation (2007)

Article

Acinus-provoked protein kinase C δ isoform activation is essential for apoptotic chromatin condensation

Histone H2B phosphorylation tightly correlates with chromatin condensation during apoptosis. The caspase-cleaved acinus (apoptotic chromatin condensation inducer in the nucleus) provokes chromatin condensation in...

Y Hu, Z Liu, S-J Yang, K Ye in Cell Death & Differentiation (2007)

Article

Transcriptional activation of caspase-6 and -7 genes by cisplatin-induced p53 and its functional significance in cisplatin nephrotoxicity

This study examined the role of cisplatin-induced p53 activation in regulation of caspases and cellular injury during cisplatin nephrotoxicity. The executioner caspase-6 and -7 but not caspase-3 were identifie...

C Yang, V Kaushal, R S Haun, R Seth, S V Shah, G P Kaushal in Cell Death & Differentiation (2008)

Article

EGL-1 BH3 mutants reveal the importance of protein levels and target affinity for cell-killing potency

Studies of the cell death pathway in the nematode Caenorhabditis elegans provided the first evidence of the evolutionary conservation of apoptosis signalling. Here we show that the worm Bcl-2 homology domain-3 (B...

E F Lee, L Chen, H Yang, P M Colman, D C S Huang… in Cell Death & Differentiation (2008)

Article

Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands

Apoptosis is an important part of the host's defense mechanism for eliminating invading pathogens. Some viruses express proteins homologous in sequence and function to mammalian pro-survival Bcl-2 proteins. An...

M Kvansakul, H Yang, W D Fairlie, P E Czabotar, S F Fischer… in Cell Death & Differentiation (2008)