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  1. No Access

    Article

    The dopamine D2 receptor partial agonist aplindore improves motor deficits in MPTP-treated common marmosets alone and combined with l-dopa

    Dopamine replacement therapy in Parkinson’s disease (PD) using l-dopa is invariably associated with a loss of drug efficacy (“wearing off”) and the onset of dyskinesia. The use of dopamine receptor partial agonis...

    Michael John Jackson, Terrance H. Andree, Matthew Hansard… in Journal of Neural Transmission (2010)

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    Article

    WAY-163909, a 5-HT2C agonist, enhances the preclinical potency of current antipsychotics

    5-HT2C agonists, by decreasing mesolimbic dopamine without affecting nigrostriatal dopamine, are predicted to have antipsychotic efficacy with low extrapyramidal side effects (EPS). Combining 5-HT2C agonists with...

    Steven M. Grauer, Radka Graf, Rachel Navarra, Amy Sung… in Psychopharmacology (2009)

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    Article

    Antidepressant-like effects of the novel, selective, 5-HT2C receptor agonist WAY-163909 in rodents

    Activation of one or more of the serotonin (5-HT) receptors may play a role in mediating the antidepressant effects of SSRIs.

    Sharon Rosenzweig-Lipson, Annmarie Sabb, Gary Stack, Paul Mitchell… in Psychopharmacology (2007)