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Article
Open AccessCareer destinations of graduates from a medical school with an 18-week longitudinal integrated clerkship in general practice: a survey of alumni 6 to 8 years after graduation
There is a worldwide recruitment and retention crisis in general practice. Workforce planning has identified the need to train more general practitioners as an urgent priority. Exposure of medical students to ...
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Article
Open AccessThe University of Limerick Education and Research Network for General Practice (ULEARN-GP): practice characteristics and general practitioner perspectives
A well-functioning general practice sector that has a strong research component is recognised as a key foundation of any modern health system. General practitioners (GPs) are more likely to collaborate in rese...
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Article
The dopamine D2 receptor partial agonist aplindore improves motor deficits in MPTP-treated common marmosets alone and combined with l-dopa
Dopamine replacement therapy in Parkinson’s disease (PD) using l-dopa is invariably associated with a loss of drug efficacy (“wearing off”) and the onset of dyskinesia. The use of dopamine receptor partial agonis...
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Article
WAY-163909, a 5-HT2C agonist, enhances the preclinical potency of current antipsychotics
5-HT2C agonists, by decreasing mesolimbic dopamine without affecting nigrostriatal dopamine, are predicted to have antipsychotic efficacy with low extrapyramidal side effects (EPS). Combining 5-HT2C agonists with...
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Article
Antidepressant-like effects of the novel, selective, 5-HT2C receptor agonist WAY-163909 in rodents
Activation of one or more of the serotonin (5-HT) receptors may play a role in mediating the antidepressant effects of SSRIs.
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Leukodepletion to Prevent Transfusion Reactions: Effects on Cytokines and Other Biologic Response Modifiers
The role of allogeneic leukocytes in causing febrile nonhemolytic transfusion (FNHTR) reactions has been known since the mid-1950s. Recent data suggests plausible mechanisms in which pro-inflammatory cytokine...