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WAY-163909, a 5-HT2C agonist, enhances the preclinical potency of current antipsychotics
5-HT2C agonists, by decreasing mesolimbic dopamine without affecting nigrostriatal dopamine, are predicted to have antipsychotic efficacy with low extrapyramidal side effects (EPS). Combining 5-HT2C agonists with...
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Article
Antidepressant-like effects of the novel, selective, 5-HT2C receptor agonist WAY-163909 in rodents
Activation of one or more of the serotonin (5-HT) receptors may play a role in mediating the antidepressant effects of SSRIs.
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Leukodepletion to Prevent Transfusion Reactions: Effects on Cytokines and Other Biologic Response Modifiers
The role of allogeneic leukocytes in causing febrile nonhemolytic transfusion (FNHTR) reactions has been known since the mid-1950s. Recent data suggests plausible mechanisms in which pro-inflammatory cytokine...