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Open AccessEvidence of gene-nutrient interaction association with waist circumference, cross-sectional analysis
Waist circumference (WC) is a significant indicator of body adiposity and is associated with increased mortality and morbidity of cardiovascular diseases. Although, single nutrient intake and candidate genes w...
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Article
Open AccessGenetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits
We evaluate the shared genetic regulation of mRNA molecules, proteins and metabolites derived from whole blood from 3029 human donors. We find abundant allelic heterogeneity, where multiple variants regulate a...
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Open AccessAuthor Correction: Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models
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Retraction Note: Dietary metabotype modelling predicts individual responses to dietary interventions
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Open AccessDiscovery of drug–omics associations in type 2 diabetes with generative deep-learning models
The application of multiple omics technologies in biomedical cohorts has the potential to reveal patient-level disease characteristics and individualized response to treatment. However, the scale and heterogen...
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Open AccessMulti-omic phenoty** reveals host-microbe responses to bariatric surgery, glycaemic control and obesity
Resolution of type 2 diabetes (T2D) is common following bariatric surgery, particularly Roux-en-Y gastric bypass. However, the underlying mechanisms have not been fully elucidated.
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Open AccessMinor changes in fibre intake in the UK population between 2008/2009 and 2016/2017
The benefits of increasing populations’ and individuals’ fibre intake on non-communicable disease risk have been known and promoted for decades in the UK and in the world. Public health campaigns, including di...
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Open AccessThe Effect of a Single Bout of Continuous Aerobic Exercise on Glucose, Insulin and Glucagon Concentrations Compared to Resting Conditions in Healthy Adults: A Systematic Review, Meta-Analysis and Meta-Regression
Elevated glucose and insulin levels are major risk factors in the development of cardiometabolic disease. Aerobic exercise is widely recommended to improve glycaemic control, yet its acute effect on glycaemia ...
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Open AccessIncidence and predictors of hospital readmission in children presenting with severe anaemia in Uganda and Malawi: a secondary analysis of TRACT trial data
Severe anaemia (haemoglobin < 6 g/dL) is a leading cause of recurrent hospitalisation in African children. We investigated predictors of readmission in children hospitalised with severe anaemia in the TRACT tr...
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Author Correction: Nutriome–metabolome relationships provide insights into dietary intake and metabolism
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Correction to: The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study
Unfortunately, ‘Present address’ was omitted from one of the addresses provided for Mark I. McCarthy (#26).
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Short-chain fatty acids as potential regulators of skeletal muscle metabolism and function
A key metabolic activity of the gut microbiota is the fermentation of non-digestible carbohydrate, which generates short-chain fatty acids (SCFAs) as the principal end products. SCFAs are absorbed from the gut...
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Identifying unknown metabolites using NMR-based metabolic profiling techniques
Metabolic profiling of biological samples provides important insights into multiple physiological and pathological processes but is hindered by a lack of automated annotation and standardized methods for struc...
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Nutriome–metabolome relationships provide insights into dietary intake and metabolism
Dietary assessment traditionally relies on self-reported data, which are often inaccurate and may result in erroneous diet–disease risk associations. We illustrate how urinary metabolic phenoty** can be used...
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RETRACTED ARTICLE: Dietary metabotype modelling predicts individual responses to dietary interventions
Habitual consumption of poor quality diets is linked directly to risk factors for many non-communicable diseases. This has resulted in the vast majority of countries and the World Health Organization developin...
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Open AccessThe role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study
It is well established that physical activity, abdominal ectopic fat and glycaemic regulation are related but the underlying structure of these relationships is unclear. The previously proposed twin-cycle hypo...
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Open AccessDiscovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium
Here, we describe the characteristics of the Innovative Medicines Initiative (IMI) Diabetes Research on Patient Stratification (DIRECT) epidemiological cohorts at baseline and follow-up examinations (18, 36 an...
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Open AccessA randomized controlled trial for overweight and obesity in preschoolers: the More and Less Europe study - an intervention within the STOP project
Childhood overweight and obesity is a serious public health issue with an increase being observed in preschool-aged children. Treating childhood obesity is difficult and few countries use standardized treatmen...
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Open AccessA cross-sectional investigation into the occupational and socio-demographic characteristics of British police force employees reporting a dietary pattern associated with cardiometabolic risk: findings from the Airwave Health Monitoring Study
The aims of this study were to (1) determine the association between diet quality using the Dietary Approaches to Stop Hypertension (DASH) score and cardiometabolic risk in a British working population and (2)...
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Open AccessRole of Gut Microbiota-Generated Short-Chain Fatty Acids in Metabolic and Cardiovascular Health
This review assesses the latest evidence linking short-chain fatty acids (SCFA) with host metabolic health and cardiovascular disease (CVD) risk and presents the latest evidence on possible biological mechanisms.
