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Article
Open AccessBayesian-frequentist hybrid inference framework for single cell RNA-seq analyses
Single cell RNA sequencing technology (scRNA-seq) has been proven useful in understanding cell-specific disease mechanisms. However, identifying genes of interest remains a key challenge. Pseudo-bulk methods t...
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Article
Facial emotion recognition function and white matter microstructural alterations in drug-naive, comorbidity-free autism
Individuals with autism spectrum disorder have deficits in facial emotion recognition and white matter microstructural alterations. Nonetheless, most previous studies were confounded by different variables, su...
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Article
Study on physical and mechanical properties of oil shale ash–based green mining filling materials
The utilization of oil shale ash in develo** environmentally sustainable filling materials for subterranean mines presents a promising ecological approach, albeit with typically low ash content. In this stud...
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Article
A Three-dimensional Anisotropic Creep Model for Predicting the Time-dependent Deformation of Layered Rock Mass
Characterizing layered rock's anisotropic creep is crucial for assessing the potential effect of anisotropic creep on the long-term stability of engineering structures. This study establishes a new anisotropic...
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Article
Open AccessBacteriophage EPP-1, a potential antibiotic alternative for controlling edwardsiellosis caused by Edwardsiella piscicida while mitigating drug-resistant gene dissemination
Edwardsiella piscicida causes significant economic losses to the aquaculture industry worldwide. Phage-based biocontrol methods are experiencing a renaissance because of the spread of drug-resistant genes and bac...
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Article
Open AccessX-ray-activated polymerization expanding the frontiers of deep-tissue hydrogel formation
Photo-crosslinking polymerization stands as a fundamental pillar in the domains of chemistry, biology, and medicine. Yet, prevailing strategies heavily rely on ultraviolet/visible (UV/Vis) light to elicit in s...
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Article
Open AccessAlternations in the human skin, gut and vaginal microbiomes in perimenopausal or postmenopausal Vulvar lichen sclerosus
Vulvar lichen sclerosus (VLS) is a chronic and progressive dermatologic condition that can cause physical dysfunction, disfigurement, and impaired quality of life. However, the etiology of VLS remains unknown....
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Article
Triplet–triplet annihilation photon upconversion-mediated photochemical reactions
Photon upconversion is a method for harnessing high-energy excited states from low-energy photons. Such photons, particularly in the red and near-infrared wavelength ranges, can penetrate tissue deeply and und...
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Article
Open AccessResearch on the variation law of floor stress information entropy in upper protective layer mining based on Brillouin optical fiber sensing
The characteristics of floor failure and stress changes during the mining process of protective layers are crucial for determining the effectiveness of pressure relief. Three boreholes were designed in the 211...
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Chapter and Conference Paper
DP-Loc: A Differential Privacy-Based Indoor Localization Scheme with Bilateral Privacy Protection
Among indoor localization services, WiFi fingerprint technology has attracted much attention because of its wide coverage area and high positioning accuracy. However, concerns arise regarding the vulnerability...
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Protocol
Nano-optogenetic CAR-T Cell Immunotherapy
Chimeric antigen receptor (CAR)-T cell immunotherapy emerges as an effective cancer treatment. However, significant safety concerns remain, such as cytokine release syndrome (CRS) and “on-target, off-tumor” cy...
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Chapter and Conference Paper
Research and Demonstration Verification of Flexible Interconnection Operation Control and Fault Defense Strategies for Microgrid Groups Based on Multiflow Fusion
In this paper, the requirements of digital transformation of distribution network are analyzed, the concept of “energy-information-control-service” multi-flow fusion of distribution network is proposed, and th...
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Chapter
Technologies for the Surface Functionalization of Extracellular Vesicles
Extracellular vesicles (EVs) are biological nanovesicles secreted by the majority of cells and can be found in all kingdoms of life. EVs show promise in diagnostics and therapeutics owing to their intrinsic ro...
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Article
Open AccessGroup-based trajectory analysis identifies varying diabetes-related cost trajectories among type 2 diabetes patients in Texas: an empirical study using commercial insurance
The trend of Type 2 diabetes-related costs over 4 years could be classified into different groups. Patient demographics, clinical factors (e.g., A1C, short- and long-term complications), and rurality could be ...
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Article
Open AccessCost-effectiveness analysis of pembrolizumab versus chemotherapy as first-line treatment for mismatch-repair-deficient (dMMR) or microsatellite-instability-high (MSI-H) advanced or metastatic colorectal cancer from the perspective of the Chinese health-care system
Pembrolizumab is superior to chemotherapy as a first-line treatment for patients with mismatch-repair-deficient (dMMR) or microsatellite-instability-high (MSI-H) advanced or metastatic colorectal cancer (CRC),...
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Article
A Framework for RQD Calculation Based on Deep Learning
The rock quality designation (RQD) is a commonly used index for the classification and evaluation of rock mass quality and is widely adopted in mining and geological engineering. The traditional method of obta...
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Article
Open AccessQuantitative dynamic contrast-enhance MRI parameters for rectal carcinoma characterization: correlation with tumor tissue composition
To investigate the relationship between dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) measurements and the potential composition of rectal carcinoma.
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Article
Visible dynamic changes in the mechanism of water evaporation surface formation during wood drying
Internal moisture distribution seriously affects timber shrinkage relations during drying, and it is also an essential parameter for testing the validity of a three-dimensional heat and mass transfer model. He...
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Article
Open AccessAn extraordinary fossil captures the struggle for existence during the Mesozoic
Dinosaurs and mammals have coexisted for the last ~ 230 million years. Both groups arose during the Late Triassic and diversified throughout the Mesozoic and into the Cenozoic (the latter in the form of birds)...
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Article
Open AccessThe Cas9-gRNA ribonucleoprotein complex-mediated editing of pyrG in Ganoderma lucidum and unexpected insertion of contaminated DNA fragments
Gene editing is a promising alternative to traditional breeding for the generation of new mushroom strains. However, the current approach frequently uses Cas9-plasmid DNA to facilitate mushroom gene editing, w...
