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Article
Open AccessCo-localization of clusters of TCR-regulated genes with TAD rearrangements
Gene expression has long been known to be influenced by the relative proximity of DNA regulatory elements. Topologically associating domains (TADs) are self-interacting genomic regions involved in regulating g...
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Article
Cancer aneuploidies are shaped primarily by effects on tumour fitness
Aneuploidies—whole-chromosome or whole-arm imbalances—are the most prevalent alteration in cancer genomes1,2. However, it is still debated whether their prevalence is due to selection or ease of generation as pas...
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Article
Open AccessAnalysis of KIR gene variants in The Cancer Genome Atlas and UK Biobank using KIRCLE
Natural killer (NK) cells represent a critical component of the innate immune system’s response against cancer and viral infections, among other diseases. To distinguish healthy host cells from infected or tum...
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Article
Open AccessAuthor Correction: Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells
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Article
Open AccessLoss of heterozygosity of essential genes represents a widespread class of potential cancer vulnerabilities
Alterations in non-driver genes represent an emerging class of potential therapeutic targets in cancer. Hundreds to thousands of non-driver genes undergo loss of heterozygosity (LOH) events per tumor, generati...
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Article
Open AccessIdentification of ADAR1 adenosine deaminase dependency in a subset of cancer cells
Systematic exploration of cancer cell vulnerabilities can inform the development of novel cancer therapeutics. Here, through analysis of genome-scale loss-of-function datasets, we identify adenosine deaminase ...
