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Article
Open AccessIn vitro and in vivo evaluation of NCX 4040 cytotoxic activity in human colon cancer cell lines
Nitric oxide-releasing nonsteroidal antiinflammatory drugs (NO-NSAIDs) are reported to be safer than NSAIDs because of their lower gastric toxicity. We compared the effect of a novel NO-releasing derivate, NCX...
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The Role Of C-Myb In Gastrointestinal Tract Development And Carcinogenesis
The list of cancers in which c-Myb appears to play a role includes tumours of the upper gastrointestinal (GI) tract, colon, pancreas, melanocytes, brain and breast. This review focuses on the involvement of c-...
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Article
Treatment of melanoma cells with a bcl-2/bcl-xL antisense oligonucleotide induces antiangiogenic activity
We have recently reported that bcl-2 overexpression and hypoxia synergistically interact to modulate vascular endothelial growth factor (VEGF) and in vivo angiogenesis in tumour cells through VEGF mRNA stabilizat...
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Article
The future of antisense therapy: combination with anticancer treatments
The current direction in cancer research is rational drug design, which is based on the evidence that transformed cells are characterized by alterations of genes devoted to the regulation of both cell prolifer...
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Article
Reconstitution of hTERT restores tumorigenicity in melanoma-derived c-Myc low-expressing clones
c-Myc is involved in the control of telomerase activity through its ability to induce the expression of the catalytic subunit of the enzyme, the human telomerase reverse transcriptase (hTERT). Our aim was to s...
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Article
Encapsulation of c-myc antisense oligodeoxynucleotides in lipid particles improves antitumoral efficacy in vivo in a human melanoma line
Phosphorothioate c-myc antisense oligodeoxynucleotides [S]ODNs (free INX-6295) were encapsulated in a new liposome formulation and the antitumor activity was compared to the unencapsulated antisense in a human...
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Article
Establishment of cell lines from serial samples from two patients with lung tumours before and after chemotherapy
Six cell lines were derived from pleural effusions of two lung cancer patients and established in vitro in our laboratory. Cell line AE1 was obtained from a small cell lung cancer (SCLC) before the patient had re...
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Article
Effect of lonidamine on human malignant gliomas: Biochemical studies
Lonidamine (LND) has been shown to inhibit tumor aerobic glycolysis. Its effect was evaluated on several human astrocytomas at different degrees of malignancy; a correlation was found between LDN effect on lac...
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Article
Establishment, characterization and chemosensitivity of two human glioma derived cell lines
Two continuous human glioma derived cell lines, LI and DF, were established in our laboratory. Both cell lines showed cytological features andin vitro behavior similar to those of the respective original neoplasm...
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Article
Changes of phenotypic characteristics of variants derived from Lewis lung carcinoma during long-term in vitro growth
Two cultured cell clones derived from Lewis lung carcinoma (3LL), which have been shown to differ in their metastatic potential, were studied for their phenotypic stability in vitro. Several growth properties (la...
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Article
Influence of scheduling on therapeutic and toxic effect of AMSA in Lewis lung carcinoma
The antitumor activity and toxic effect of AMSA were studied in Lewis lung carcinoma (3LL) at various stages of growth. The total dose of drug injected IP was 15 mg/kg, which is equivalent to the LD10. Different ...
