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  1. Article

    Open Access

    Lactate secreted by glycolytic conjunctival melanoma cells attracts and polarizes macrophages to drive angiogenesis in zebrafish xenografts

    Conjunctival melanoma (CoM) is a rare but potentially lethal cancer of the eye, with limited therapeutic option for metastases. A better understanding how primary CoM disseminate to form metastases is urgently...

    Jie Yin, Gabriel Forn-Cuní, Akshaya Mahalakshmi Surendran… in Angiogenesis (2024)

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  2. Article

    Open Access

    Metabolomic and transcriptomic profiling of adult mice and larval zebrafish leptin mutants reveal a common pattern of changes in metabolites and signaling pathways

    Leptin plays a critical role in the regulation of metabolic homeostasis. However, the molecular mechanism and cross talks between leptin and metabolic pathways leading to metabolic homeostasis across different...

    Yi Ding, Mariëlle C. Haks, Gabriel Forn-Cuní, Junling He… in Cell & Bioscience (2021)

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  3. Article

    Open Access

    Deficiency in the autophagy modulator Dram1 exacerbates pyroptotic cell death of Mycobacteria-infected macrophages

    DNA damage regulated autophagy modulator 1 (DRAM1) is a stress-inducible regulator of autophagy and cell death. DRAM1 has been implicated in cancer, myocardial infarction, and infectious diseases, but the mole...

    Rui Zhang, Monica Varela, Gabriel Forn-Cuní, Vincenzo Torraca… in Cell Death & Disease (2020)

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