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Article
Open AccessComparison of Flow Reduction Efficacy of Nominal and Oversized Flow Diverters Using a Novel Measurement-assisted in Silico Method
The high efficacy of flow diverters (FD) in the case of wide-neck aneurysms is well demonstrated, yet new challenges have arisen because of reported posttreatment failures and the growing number of new generat...
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Protocol
Cellular Blood Flow Modeling with HemoCell
Many of the intriguing properties of blood originate from its cellular nature. Bulk effects, such as viscosity, depend on the local shear rates and on the size of the vessels. While empirical descriptions of b...
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Chapter
Fractals and Chaos in the Hemodynamics of Intracranial Aneurysms
Computing the emerging flow in blood vessel sections by means of computational fluid dynamics is an often applied practice in hemodynamics research. One particular area for such investigations is related to th...
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Chapter and Conference Paper
A Three-Dimensional Fluid-Structure Interaction Model for Platelet Aggregates Based on Porosity-Dependent Neo-Hookean Material
The stability of the initial platelet aggregates is relevant in both hemostasis and thrombosis. Understanding the structural stresses of such aggregates under different flow conditions is crucial to gaining in...
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Chapter and Conference Paper
Simulating Initial Steps of Platelet Aggregate Formation in a Cellular Blood Flow Environment
The mechano-chemical process of clot formation is relevant in both hemostasis and thrombosis. The initial phase of thrombus formation in arterial thrombosis can be described by the mechanical process of platel...
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Chapter and Conference Paper
Building a Fine-Grained Analytical Performance Model for Complex Scientific Simulations
Analytical performance models are powerful for understanding and predicting the performance of large-scale simulations. As such, they can help identify performance bottlenecks, assess the effect of load imbala...
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Article
Open AccessThe Effects of Micro-vessel Curvature Induced Elongational Flows on Platelet Adhesion
The emerging profile of blood flow and the cross-sectional distribution of blood cells have far reaching biological consequences in various diseases and vital internal processes, such as platelet adhesion. The...
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Chapter and Conference Paper
Two-Way Coupling Between 1D Blood Flow and 3D Tissue Perfusion Models
Accurately predicting brain tissue perfusion and infarct volume after an acute ischaemic stroke requires the two-way coupling of perfusion models on multiple scales. We present a method for such two-way coupli...
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Article
Open AccessBiorheology of occlusive thrombi formation under high shear: in vitro growth and shrinkage
Occlusive thrombi formed under high flow shear rates develop very rapidly in arteries and may lead to myocardial infarction or stroke. Rapid platelet accumulation (RPA) and occlusion of platelet-rich thrombi a...
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Article
Open AccessHydrodynamic Resistance of Intracranial Flow-Diverter Stents: Measurement Description and Data Evaluation
Intracranial aneurysms are malformations forming bulges on the walls of brain arteries. A flow diverter device is a fine braided wire structure used for the endovascular treatment of brain aneurysms. This work...
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Chapter and Conference Paper
A Heterogeneous Multi-scale Model for Blood Flow
This research focuses on develo** a heterogeneous multi-scale model (HMM) for blood flow. Two separate scales are considered in this study, a Macro-scale, which models whole blood as a continuous fluid and t...
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Article
Multiple Aneurysms AnaTomy CHallenge 2018 (MATCH)—phase II: rupture risk assessment
Assessing the rupture probability of intracranial aneurysms (IAs) remains challenging. Therefore, hemodynamic simulations are increasingly applied toward supporting physicians during treatment planning. Howeve...
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Chapter and Conference Paper
Optimizing Parallel Performance of the Cell Based Blood Flow Simulation Software HemoCell
Large scale cell based blood flow simulations are expensive, both in time and resource requirements. HemoCell can perform such simulations on high performance computing resources by dividing the simulation dom...
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Chapter and Conference Paper
Understanding Malaria Induced Red Blood Cell Deformation Using Data-Driven Lattice Boltzmann Simulations
Malaria remains a deadly disease that affected millions of people in 2016. Among the five Plasmodium (P.) parasites which contribute to malaria diseases in humans. P. falciparum is a lethal one which is respon...
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Chapter
Fractals and Chaos in the Hemodynamics of Intracranial Aneurysms
Computing the emerging flow in blood vessel sections by means of computational fluid dynamics is an often applied practice in hemodynamics research. One particular area for such investigations is related to th...
