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Article
Open AccessUpdated results from the phase 3 HELIOS study of ibrutinib, bendamustine, and rituximab in relapsed chronic lymphocytic leukemia/small lymphocytic lymphoma
We report follow-up results from the randomized, placebo-controlled, phase 3 HELIOS trial of ibrutinib+bendamustine and rituximab (BR) for previously treated chronic lymphocytic leukemia (CLL)/small lymphocyti...
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Article
Open AccessCo-expression of truncated and full-length tau induces severe neurotoxicity
Abundant tau inclusions are a defining hallmark of several human neurodegenerative diseases, including Alzheimer’s disease. Protein fragmentation is a widely observed event in neurodegenerative proteinopathies...
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Article
Common variant at 16p11.2 conferring risk of psychosis
Epidemiological and genetic data support the notion that schizophrenia and bipolar disorder share genetic risk factors. In our previous genome-wide association study, meta-analysis and follow-up (totaling as m...
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Article
The Large Observatory for X-ray Timing (LOFT)
High-time-resolution X-ray observations of compact objects provide direct access to strong-field gravity, to the equation of state of ultradense matter and to black hole masses and spins. A 10 m2-class instrument...
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Article
Lunar Net—a proposal in response to an ESA M3 call in 2010 for a medium sized mission
Emplacement of four or more kinetic penetrators geographically distributed over the lunar surface can enable a broad range of scientific exploration objectives of high priority and provide significant synergy ...
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Article
Expanding the range of ZNF804A variants conferring risk of psychosis
A trio of genome-wide association studies recently reported sequence variants at three loci to be significantly associated with schizophrenia. No sequence polymorphism had been unequivocally (P<5 × 10−8) associat...
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Article
Copy number variations of chromosome 16p13.1 region associated with schizophrenia
Deletions and reciprocal duplications of the chromosome 16p13.1 region have recently been reported in several cases of autism and mental retardation (MR). As genomic copy number variants found in these two dis...
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Article
A threonine to isoleucine missense mutation in the pericentriolar material 1 gene is strongly associated with schizophrenia
Markers at the pericentriolar material 1 gene (PCM1) have shown genetic association with schizophrenia in both a University College London (UCL) and a USA-based case–control sample. In this paper we report a stat...
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Article
Bispectral index and suppression ratio are very early predictors of neurological outcome during therapeutic hypothermia after cardiac arrest
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Article
Using formal methods for ensuring quality requirements of systems
Ensuring a system's safety, security and functional requirements are important tasks with growing interests in industry. These interests hold especially for companies that deal with safety critical systems. In...
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Article
Impact of early sepsis on oxygen delivery in the microvasculature
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Article
Increased leukocyte transit times through capillaries contributes to maldistribution of flow
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Article
Impact of early sepsis on oxygen delivery in the microvasculature
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Article
Effects of the carcinogen dimethylhydrazine (DMH) on the function of rat colonic crypts
Rats injected with dimethylhydrazine for 5 weeks (DMH, 40 mg/kg body weight) invariably develop colonic cancer after a latency of some 10–14 weeks. Preliminary studies have suggested that Na+ absorption by surfa...
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Article
The ion conductances of colonic crypts from dexamethasone-treated rats
Whole-cell patch-clamp studies were performed in isolated colonic crypts of rats pretreated with dexamethasone (6 mg/kg subcutaneously on 3 days consecutively prior to the experiment). The cells were divided i...
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Article
Occupational physical activity and risk of cancer of the colon and rectum in New Zealand males
The association between occupational physical activity and risk of colorectal cancer by age and anatomic site was investigated in a study of 2,503 males with colorectal cancer registered with the New Zealand C...
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Article
SXRP: an X-ray polarimeter for the SPECTRUM-X-Gamma Mission
TheStellar X-ray Polarimeter (SXRP) is a focal plane instrument which will be flown on the SPECTRUM-X-Gamma mission in 1993. The polarimeter is composed of two separate instruments: the first exploits the depende...
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Article
A cAMP-activated chloride channel in the plasma membrane of cultured human gastric cells (HGT-1)
Hydrochloric acid (HCl) secretion by gastric parietal cells involves an apical Cl− conductance, the properties of which have not been defined. In the present study, forskolin and histamine [agonists that increase...
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Chapter and Conference Paper
The Stellar X-Ray Polarimeter for the SPECTRUM-X-Gamma Mission
We describe an X-ray polarimeter which will be flown on the SPECTRUM-X-Gamma mission. The instrument exploits three distinct physical processes to measure polarization: Bragg reflection from a graphite crystal...
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Chapter
Laser Raman Spectroscopy on Synthetic Polymers
Laser Raman spectroscopy, a light scattering process, has undergone a renaissance over the last ten years thanks to the development of the laser. In this chapter we describe one of its more successful areas of...
