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Article
RhoA and RhoC are both required for the ROCK II-dependent promotion of centrosome duplication
CDK2-cyclin E triggers centrosome duplication, and nucleophosmin (NPM/B23) is found to be one of its targets. NPM/B23 phosphorylated by CDK2-cyclin E acquires a high binding affinity to Rho-associated kinase (...
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Article
Evidence that MIG-6 is a tumor-suppressor gene
Mitogen-inducible gene 6 (MIG-6) is located in human chromosome 1p36, a locus frequently associated with human lung cancer. MIG-6 is a negative regulator of epidermal growth factor (EGF) signaling, and we show th...
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Article
Anthrax toxins
Though its lethal effects were ascribed to an exotoxin almost half a century ago, the pathogenesis of anthrax has yet to be satisfactorily explained. Subsequent work has led to the molecular identification an...
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Chapter
The Multiple Roles of Mos during Meiosis
The technique of microinjection has been a critical aspect of experiments which have elucidated the normal function of the Mos oncogene. This technique has also been used to dissect the signal transduction pat...
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Chapter
The Met-HGF/SF autocrine signaling mechanism is involved in sarcomagenesis
Hepatocyte growth factor/scatter factor (HGF/SF) can elicit a wide variety of effects upon cells expressing its receptor, the tyrosine kinase proto-oncogene product Met, including mitogenicity, motility, and m...
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Chapter and Conference Paper
Activation of the met Proto-oncogene in a Human Cell Line
The met oncogene was identified in the MNNG-HOS cell line, derived by extensive treatment of a human osteosarcoma cell line (HOS) with N-methyl-N-N′-nitrosogua-nidine (MNNG) [1]. DNA from MNNG-HOS cells was used ...
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Chapter
The Genetic Basis of Retroviral-Induced Transformation
The mammalian leukemia viruses and the avian leukosis viruses produce tumors in animals after long latent periods. In contrast, the acute transforming retroviruses produce a variety of neoplasias within weeks ...
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Chapter and Conference Paper
The Long Terminal Repeat of Moloney Sarcoma Provirus Enhances Transformation
Transforming retroviruses are generally thought to arise from a recombination between nontransforming viruses and sequences of cellular origin. Until recently, it has not been possible to test whether the acqu...
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Article
Purification of Herpesvirus saimiri and properties of the viral DNA
Conditions for growth, concentration, and purification of Herpesvirus saimiri were determined. Optimal yields of infectious Herpesvirus saimiri (HVS) were obtained from infected owl monkey kidney (OMK) cells g...
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Article
Translation products of foot-and-mouth disease virus-infected baby hamster kidney cells
Electrophoretic analysis of the polypeptides present in foot-and-mouth disease virus (FMDV) infected cells indicates that the viral ribonucleic acid (RNA), as with other picornaviruses is translated to produce...
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Article
Evidence for a single structural polypeptide in foot-and-mouth disease virus
Foot-and-mouth disease virus (FMDV) degraded at low ionic-strength as well as purified viral protein (E 276 mμ 1% =11.1; max.276 mμ/min.250 mμ =3.0) were examin...
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Article
Changes in protein and nucleic acid metabolism in baby hamster kidney cells infected with foot-and-mouth disease virus
At a multiplicity of infection by foot-and-mouth disease virus sufficient to induce maximum changes in host cell metabolism, baby hamster kidney cells showed a decreased turnover of protein, RNA and DNA. Up to...
