10 Result(s)
within
G. A. Armeev
Zoology
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Article
Design of Nucleic Acid Biosensors Based on CRISPR/Cas Systems and Reporter Split Proteins
Highly sensitive, specific, rapid, and easy-to-use diagnostic methods for the detection of nucleic acids of pathogens are required for the diagnosis of many human, animal, and plant diseases and environmental ...
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Article
Investigation of the Effect of a Single-Stranded Break on the Mechanical Parameters of DNA by Molecular Dynamics Method
Early detection and repair of damaged DNA is important for cell functioning and survival. The recently proposed mechanism of intranucleosomal loop formation suggests the relaxation of DNA supercoiling accumula...
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Article
The Effect of Oncomutations and Posttranslational Modifications of Histone H1 on Chromatosome Structure and Stability
The stability of chromatosome when introducing posttranslational modifications and mutations observed in the case of oncological diseases into the structure of the linker histone was studied using bioinformati...
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Article
Construction and Analysis of Amino Acid Substitution Matrices for Optimal Alignment of Microbial Rhodopsin Sequences
Pairwise alignment of amino acid sequences is the basic tool of bioinformatics, which is widely used both independently and within numerous more complex methods. The effectiveness of this tool critically depen...
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Article
Joint Effect of Histone H1 Amino Acid Sequence and DNA Nucleotide Sequence on the Structure of Chromatosomes: Analysis by Molecular Modeling Methods
A chromatosome consisting of a nucleosome core, linker DNA, and linker histone (LH) is an important structural element of chromatin and plays a role in replication and transcription regulation. There are two e...
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Article
Investigation of histone-DNA binding energy as a function of DNA unwrap** from nucleosome using molecular modeling
The present study contributes to the understanding of DNA compaction in the cell nucleus at the nucleosomal level. The interaction between DNA and histones affects key processes of cell life, including replica...
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Article
Nucleosome structure relaxation during DNA unwrap**: Molecular dynamics simulation study
Effects of local relaxation of the nucleosome structure after DNA unwrap** from the histone octamer are considered in this paper. The influence of charge distribution in histones on the kinetics of DNA rewra...
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Article
Modeling of the structure of protein–DNA complexes using the data from FRET and footprinting experiments
We discuss the question of constructing three-dimensional models of DNA in complex with proteins using computer modeling and indirect methods of studying the conformation of macromolecules. We consider the met...
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Article
Molecular dynamics study of the ionic environment and electrical characteristics of nucleosomes
Foundations of nucleosome structure and formation have been investigated in the present work using the molecular modeling approach. Formation of compact nucleosomes by histone proteins and parts of DNA macromo...
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Article
Conformational flexibility of nucleosomes: A molecular dynamics study
One of the major problems of molecular biology is studying the underlying principles of chromatin work. This problem is associated with understanding the processes of epigenetic regulation of gene expression, ...
