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Association between PRODH and schizophrenia is not confirmed
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Article
Support for genetic variation in neuregulin 1 and susceptibility to schizophrenia
Recently, it has been reported that genetic variants around the gene neuregulin 1 are associated with schizophrenia in an Icelandic sample. Of particular interest was the presence of a single-risk haplotype th...
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Article
Mutation screening and LD map** in the VCFS deleted region of chromosome 22q11 in schizophrenia using a novel DNA pooling approach
We examined whether variation within six genes from the VCFS critical region at 22q11 (DGSC, Stk22A1, DGSI, Gscl, Slc25A1 and Znf74) confers susceptibility to schizophrenia. We screened the exons and flanking int...
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Article
Determination of the genomic structure and mutation screening in schizophrenic individuals for five subunits of the N-methyl-D-aspartate glutamate receptor
The glutamatergic system is the major excitatory neurotransmitter system in the CNS. Glutamate receptors, and in particular N-methyl-D-aspartate (NMDA) receptors, have been proposed as mediators of many common...
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Article
Characterisation, mutation detection, and association analysis of alternative promoters and 5′ UTRs of the human dopamine D3 receptor gene in schizophrenia
The dopamine D3 receptor gene (DRD3) is a candidate for a number of psychiatric conditions including schizophrenia, bipolar disorder and alcohol and drug abuse. Previous studies have reported associations between...
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Article
Mutation screening of the KCNN3 gene reveals a rare frameshift mutation
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Article
The high affinity neurotensin receptor gene (NTSR1): comparative sequencing and association studies in schizophrenia
Neurotensin and its high affinity receptor (NTSR1) localise within dopaminergic neurones in the mesocortical, mesolimbic and nigrostriatal systems1, 2, 3, 4, 5 and it is now clear that neurotensin can selectively...
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Article
Comparative sequencing of the proneurotensin gene and association studies in schizophrenia
Neurotensin (NT) is an endogenous tridecapetide1 cleaved from a precursor proneurotensin/ proneuromedin protein. NT localises within dopaminergic neurones in the mesocortical, mesolimbic and nigrostriatal systems
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Article
Autosome search for schizophrenia susceptibility genes in multiply affected families
We have analysed 298 polymorphic markers in 13 families multiply affected with schizophrenia and related disorders using a combination of radiolabelled and fluorescent-based methodologies. The markers were dis...
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Article
Erratum: A meta-analysis and transmission disequilibrium study of association between the dopamine D3 receptor gene and schizophrenia
We performed a meta-analysis of over 30 case-control studies of association between schizophrenia and a bi-allelic, BalI polymorphism in exon 1 of the dopamine D3 receptor gene. We observed a significant exces...
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Article
Further support for an association between a polymorphic CAG repeat in the hKCa3 gene and schizophrenia
A recent study has suggested that a polymorphism in the hKCa3 potassium channel may be associated with raised susceptibility to schizophrenia.1 Despite its modest statistical significance, the study1 is intriguin...
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Article
A meta-analysis and transmission disequilibrium study of association between the dopamine D3 receptor gene and schizophrenia
We performed a meta-analysis of over 30 case-control studies of association between schizophrenia and a bi-allelic, BalI polymorphism in exon 1 of the dopamine D3 receptor gene. We observed a significant excess o...
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Article
Evidence for association between polymorphisms in the promoter and coding regions of the 5-HT2A receptor gene and response to clozapine
Clozapine is a potent atypical antipsychotic which binds to a variety of neurotransmitter receptors including serotonin (5-HT) receptors. However, the precise neurochemical site of clozapine's therapeutic acti...
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Article
A family based association study of T102C polymorphism in 5HT2A and schizophrenia plus identification of new polymorphisms in the promoter
Several studies have shown an association between schizophrenia and the C allele of a T-C polymorphism at nucleotide 102 and the 5HT2A receptor gene. In the present study we observed this association in a samp...
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Article
No evidence for expanded polyglutamine sequences in bipolar disorder and schizophrenia
Several recent studies have suggested that expanded CAG repeats may contribute to the genetic transmission of bipolar disorder and schizophrenia. In all known disorders associated with expanded CAG repeats, th...