13 Result(s)
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Article
Open AccessOcular biomarkers: useful incidental findings by deep learning algorithms in fundus photographs
Artificial intelligence can assist with ocular image analysis for screening and diagnosis, but it is not yet capable of autonomous full-spectrum screening. Hypothetically, false-positive results may have unrea...
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Article
Open AccessDetection of metastases using circulating tumour DNA in uveal melanoma
Approximately 50% of uveal melanoma (UM) patients will develop metastatic disease depending on the genetic features of the primary tumour. Patients need 3–12 monthly scans, depending on their prognosis, which ...
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Article
Open AccessL-arginine and aged garlic extract for the prevention of migraine: a study protocol for a randomised, double-blind, placebo-controlled, phase-II trial (LARGE trial)
Migraine is a common and distressing neurological condition characterised by recurrent throbbing headaches, nausea and heightened sensitivity to light and sound. Accumulating evidence suggests that cerebral ar...
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Article
Open AccessCorrecting magnification error in foveal avascular zone area measurements of optical coherence tomography angiography images with estimated axial length
To generate and validate a method to estimate axial length estimated (ALest) from spherical equivalent (SE) and corneal curvature [keratometry (K)], and to determine if this ALest can replace actual axial length ...
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Article
Open AccessLocalised relative scotoma in cuticular drusen
To investigate retinal sensitivity changes in eyes with pure cuticular drusen.
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Article
A novel phenotype in a family with autosomal dominant retinal dystrophy due to c.1430A > G in retinoid isomerohydrolase (RPE65) and c.37C > T in bestrophin 1 (BEST1)
The c.1430A > G (Asp477Gly) variant in RPE65 has been reported in Irish and Scottish families with either an autosomal dominant retinal dystrophy (adRD) that resembles choroideremia, a vitelliform macular dystrop...
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Article
Open AccessHigh-resolution iris and retinal imaging in multisystemic smooth muscle dysfunction syndrome due to a novel Asn117Lys substitution in ACTA2: a case report
Congenital mydriasis and retinal arteriolar tortuosity are associated with the life-threatening multisystemic smooth muscle dysfunction syndrome (MSMDS) due to mutations in the gene, ACTA2, which encodes alpha-sm...
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Distortion and Scotoma Assessment in Surgical Macular Diseases
Clinical evaluation of macular disease symptoms has evolved beyond visual acuity assessment alone. Despite common usage of the Amsler grid by eye care professionals for documenting visual distortion and scotom...
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Article
Clinical and molecular characterization of non-syndromic retinal dystrophy due to c.175G>A mutation in ceroid lipofuscinosis neuronal 3 (CLN3)
Mutation of the CLN3 gene, associated with juvenile neuronal ceroid lipofuscinosis, has recently been associated with late-onset, non-syndromic retinal dystrophy. Herein we describe the multimodal imaging, immuno...
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Article
Open AccessPerifoveal interdigitation zone loss in hydroxychloroquine toxicity leads to subclinical bull’s eye lesion appearance on near-infrared reflectance imaging
To characterize the ultrastructural and functional correlates of hydroxychloroquine (HCQ)-induced subclinical bull’s eye lesion seen on near-infrared reflectance (NIR) imaging.
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Article
Open AccessDispensing Patterns of Ranibizumab and Aflibercept for the Treatment of Neovascular Age-Related Macular Degeneration: A Retrospective Cohort Study in Australia
Anti-vascular endothelial growth factor therapy is the standard of care for neovascular age-related macular degeneration (nAMD). The dosage of two licensed agents, ranibizumab and aflibercept, was established ...
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Article
Open AccessAcute progressive paravascular placoid neuroretinopathy with negative-type electroretinography in paraneoplastic retinopathy
Paraneoplastic retinopathy can be the first manifestation of systemic malignancy. A subset of paraneoplastic retinopathy is characterized by negative-type electroretinography (ERG) without fundus abnormality. ...
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Article
Open AccessProspects for clinical use of reprogrammed cells for autologous treatment of macular degeneration
Since the discovery of induced pluripotent stem cells (iPSC) in 2006, the symptoms of many human diseases have been reversed in animal models with iPSC therapy, setting the stage for future clinical developmen...
