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Article
Open AccessVisualization of accessible cholesterol using a GRAM domain-based biosensor
Cholesterol is important for membrane integrity and cell signaling, and dysregulation of the distribution of cellular cholesterol is associated with numerous diseases, including neurodegenerative disorders. Wh...
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Article
Mitochondrial damage activates the NLRP10 inflammasome
Upon detecting pathogens or cell stress, several NOD-like receptors (NLRs) form inflammasome complexes with the adapter ASC and caspase-1, inducing gasdermin D (GSDMD)-dependent cell death and maturation and r...
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Article
Open AccessCoding and non-coding roles of MOCCI (C15ORF48) coordinate to regulate host inflammation and immunity
Mito-SEPs are small open reading frame-encoded peptides that localize to the mitochondria to regulate metabolism. Motivated by an intriguing negative association between mito-SEPs and inflammation, here we scr...
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Article
Open AccessStructural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8
Nod-like receptor (NLR) proteins activate pyroptotic cell death and IL-1 driven inflammation by assembling and activating the inflammasome complex. Closely related sensor proteins NLRP1 and CARD8 undergo uniqu...
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Article
Open AccessStructural basis of RIP2 activation and signaling
Signals arising from bacterial infections are detected by pathogen recognition receptors (PRRs) and are transduced by specialized adapter proteins in mammalian cells. The Receptor-interacting-serine/threonine-...
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Article
Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells
Dyskeratosis congenita, a disease characterized by defective maintenance of blood, pulmonary and epidermal tissues, is caused by defects in genes required for telomere homeostasis. Short telomeres are thought ...
