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  1. No Access

    Book

    Immunogenetics

    Methods and Applications in Clinical Practice

    Frank T. Christiansen, Brian D. Tait in Methods in Molecular Biology (2012)

  2. No Access

    Protocol

    The Detection of NK Cell Alloreactivity by Flow Cytometric CD107a Assay

    Natural killer (NK) cell alloreactivity can be exploited in haploidentical (one haplotype mismatched) haematopoietic stem cell transplantation (HSCT) to prevent leukaemia relapse, rejection, and graft-vs-host ...

    Dianne De Santis, Bree Foley, Campbell S. Witt, Frank T. Christiansen in Immunogenetics (2012)

  3. No Access

    Article

    Duplication and Diversification of the Apolipoprotein CI (APOCI) Genomic Segment in Association with Retroelements

    We have previously shown that several multicopy gene families within the major histocompatibility complex (MHC) arose from a process of segmental duplication. It has also been observed that retroelements play...

    Elizabeth M. Freitas, Silvana Gaudieri, Wen Jie Zhang… in Journal of Molecular Evolution (2000)

  4. No Access

    Article

    The central MHC gene IKBL carries a structural polymorphism that is associated with HLA-A3,B7,DR15

     Susceptibility to several disorders, including insulin-dependent diabetes mellitus and multiple sclerosis, has been associated with alleles of HLA class II genes and loci in the TNF cluster in the central major ...

    Richard J. N. Allcock, Frank T. Christiansen, P. Price in Immunogenetics (1999)

  5. No Access

    Article

    Complete sequence of the complementC4 gene from theHLA-A1, B8, C4AQ0, C4B1, DR3 haplotype

    Daniela Ulgiati, David C. Townend, Frank T. Christiansen… in Immunogenetics (1996)

  6. No Access

    Article

    Organization and evolution of C4 and CYP21 genes in primates: importance of genomic segments

    The evolutionary relationship between two central major histocompatibility complex (MHC) genes, C4 and CYP21, was investigated by employing pulsed field gel electrophoresis (PFGE) and conventional restriction fra...

    Wen Jie Zhang, Frank T. Christiansen, **ongwen Wu, Lawrence J. Abraham… in Immunogenetics (1993)

  7. No Access

    Article

    Ancestral haplotypes reveal the role of the central MHC in the immunogenetics of IDDM

    The major histocompatibility complex (MHC) contains multiple and diverse genes which may be relevant to the induction adn regulation of autoimmune responses in insulin dependent diabetes mellitus (IDDM). In ad...

    Mariapia A. Degli-Esposti, Lawrence J. Abraham, Vincent McCann… in Immunogenetics (1992)

  8. No Access

    Article

    Genomic organization of a polymorphic duplicated region centromeric of HLA-B

    The region between tumor necrosis factor (TNF) and HLA-B in the central major histocompatibility complex (MHC) is polymorphic and associated with several autoimmune diseases. The polymorphisms are haplospecific o...

    Chanvit Leelayuwat, Lawrence J. Abraham, Hyacinth Tabarias… in Immunogenetics (1992)

  9. No Access

    Article

    An approach to the localization of the susceptibility genes for generalized myasthenia gravis by map** recombinant ancestral haplotypes

    The association of HLA A1, B8, and DR3 with generalized myasthenia gravis (GMG) ini Caucasoids is well established, but no particular gene has been implicated and there is still no adequate explanation in functio...

    Mariapia A. Degli-Esposti, Adriane Andreas, Frank T. Christiansen… in Immunogenetics (1992)

  10. No Access

    Article

    The genomic structure of two ancestral haplotypes carrying C4A duplications

    Two major histocompatibility complex (MHC) ancestral haplotypes (AH) HLA A24, Bw52, C2C, BfS, C4A3 + 2, C4BQO, DRw15, DQw6 (52.1) and HLA A24, Cw7, B7, C2C, BfS, C4A3 + 3, C4B1, DR1, DQw5 (7.2), which occur with ...

    Katsushi Tokunaga, Wen Jie Zhang, Frank T. Christiansen, Roger L. Dawkins in Immunogenetics (1991)

  11. No Access

    Chapter and Conference Paper

    Conservation Versus Polymorphism of the MHC in Relation to Transplantation, Immune Responses and Autoimmune Disease

    The MHC comprises three megabases and includes both HLA and central polymorphic non HLA genes which are relevant to the immune response. Alleles at all MHC genes occur together in specific combinations or hapl...

    Roger L. Dawkins, Mariapia P. Degli-Esposti… in Molecular Evolution of the Major Histocomp… (1991)

  12. No Access

    Article

    Differential behavior of cytotoxic effector cells against HLA antigens in strong genetic linkage disequilibrium

    Five sets of cytotoxic effector cells were generated, using haploidentical, first degree relatives in five different families, against the HLA-A3; B7 serological determinants combined with different DR antigen...

    Se Jong Kim, Frank T. Christiansen, Donald M. Silver, Bo Dupont in Immunogenetics (1981)