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Article
Open AccessOpportunities and challenges in incorporating ancillary studies into a cancer prevention randomized clinical trial
The Selenium and Vitamin E Cancer Prevention Trial (SELECT) was a randomized, double-blind, placebo-controlled, prostate cancer prevention study funded by the National Cancer Institute and conducted by SWOG (S...
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Article
Open AccessRandomized trial of medroxyprogesterone acetate for the prevention of endometrial pathology from adjuvant tamoxifen for breast cancer: SWOG S9630
The proliferative effect of adjuvant tamoxifen on the endometrium can potentially result in endometrial abnormalities, including cancer in postmenopausal women. We conducted a randomized, controlled trial to a...
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Article
Open AccessRole of obesity in a randomized placebo-controlled trial of difluoromethylornithine (DFMO) + sulindac for the prevention of sporadic colorectal adenomas
Chemoprevention with the polyamine-inhibitory regimen difluoromethylornithine (DFMO) + sulindac markedly reduces risk of recurrent adenoma in colorectal adenoma patients. Obesity is associated with risk of col...
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Chapter
Thinking About the Role (Largely Ignored) of Heavy Metals in Cancer Prevention: Hexavalent Chromium and Melanoma as a Case in Point
Ultraviolet (UV) light exposure accounts for only 40–50% of the attributable risk for cutaneous melanoma (CM); also classical UV-induced lesions are rare in melanomas (especially among CM with NRAS or BRAF mut...
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Chapter and Conference Paper
Can a Marker Be a Surrogate for Development of Cancer, and Would We Know It if It Exists?
Carcinogenesis proceeds through a very long preclinical period. Our collective hope is that multiple opportunities exist for chemoprevention to arrest or reverse progression towards malignancy. In the hope of ...
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Chapter and Conference Paper
Chemoprevention of Nonmelanoma Skin Cancer: Experience with a Polyphenol from Green Tea
Nonmelanoma skin cancer is extremely common and is increasing in incidence. It would be very useful to have forms of therapy that would prevent precancerous changes from going on to form cancer, or to reverse ...
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Chapter and Conference Paper
Dietary Fiber or Piroxicam as Potential Cancer Prevention Agents: Effects on Rectal Epithelial Cell Proliferation in Humans at Increased Risk of Colon Cancer
Over the past decade, there has been little improvement in outcome of treatment for advanced colon cancer. The best chance for cure remains early removal of a localized malignant tumor. Accordingly, much empha...
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Article
Methods for evaluating the morphological and immunohistochemical properties of human tumor colonies grown in soft agar
Clonogenic assays have been widely adopted for the investigation of hematopoietic and human tumor stem cell biology. Inasmuch as specific, whole colonies need to be analyzed morphologically, we used various me...
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Article
Quantitative association between the in vitro human tumor stem cell assay and clinical response to cancer chemotherapy
Objective methods have been developed to quantitate results of the in vitro human tumor stem cell assay, the degree of the association between the in vitro assay and clinical response as well as the likelihood...
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Article
929 INCOMPLETE LYMPHOCYTE DIFFERENTIATION IN B CELL LINES FROM IMMUNODEFICIENT PATIENTS
EBV-infected cell lines from 31 immunodeficient (ID) patients and 1 normal individual, and 7 spontaneous cell lines from cancer patients were assayed for terminal deoxynucleotidyl transferase (TdT) activity. T...
