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  1. No Access

    Article

    Phosphorylation of TSC2 by PKC-δ reveals a novel signaling pathway that couples protein synthesis to mTORC1 activity

    Downstream of insulin-like growth factor receptor, the TSC1/2/ TCB1D7 (tuberous sclerosis complex) and mTOR (mechanistic target of rapamycin) pathways are implicated in many human diseases, including cancer an...

    Jun Zhan, Raghu K. Chitta, Frank C. Harwood… in Molecular and Cellular Biochemistry (2019)

  2. Article

    Open Access

    Haploinsufficiency of the lysosomal sialidase NEU1 results in a model of pleomorphic rhabdomyosarcoma in mice

    Rhabdomyosarcoma, the most common pediatric sarcoma, has no effective treatment for the pleomorphic subtype. Still, what triggers transformation into this aggressive phenotype remains poorly understood. Here w...

    Eda R. Machado, Diantha van de Vlekkert, Heather S. Sheppard… in Communications Biology (2022)

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