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Open AccessConventional type 1 dendritic cells protect against age-related adipose tissue dysfunction and obesity
Conventional dendritic cells (cDCs) scan and integrate environmental cues in almost every tissue, including exogenous metabolic signals. While cDCs are critical in maintaining immune balance, their role in pre...
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Chapter
Sensing Tissue Damage by Myeloid C-Type Lectin Receptors
After both sterile and infectious insults, damage is inflicted on tissues leading to accidental or programmed cell death. In addition, events of programmed cell death also take place under homeostatic conditio...
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Dendritic cells in cancer immunology and immunotherapy
Dendritic cells (DCs) are a diverse group of specialized antigen-presenting cells with key roles in the initiation and regulation of innate and adaptive immune responses. As such, there is currently much inter...
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Article
A natural killer–dendritic cell axis defines checkpoint therapy–responsive tumor microenvironments
Intratumoral stimulatory dendritic cells (SDCs) play an important role in stimulating cytotoxic T cells and driving immune responses against cancer. Understanding the mechanisms that regulate their abundance i...
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Article
Open AccessEnhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8+ T cells
The goal of successful anti-tumoural immunity is the development of long-term protective immunity to prevent relapse. Infiltration of tumours with CD8+ T cells with a resident memory (Trm) phenotype correlates wi...
