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  1. Article

    Open Access

    Engineering Structurally Interacting RNA (sxRNA)

    RNA-based three-way junctions (3WJs) are naturally occurring structures found in many functional RNA molecules including rRNA, tRNA, snRNA and ribozymes. 3WJs are typically characterized as resulting from an R...

    Francis Doyle, Sameer Lapsia, Salvatore Spadaro, Zachary E. Wurz… in Scientific Reports (2017)

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    RIP: An mRNA Localization Technique

    A detailed understanding of post-transcriptional gene expression is necessary to correlate the different elements involved in the many levels of RNA–protein interactions that are needed to coordinate the cellu...

    Sabarinath Jayaseelan, Francis Doyle, Salvatore Currenti… in RNA Detection and Visualization (2011)

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    RIP-CHIP in Drug Development

    Microarrays are extensively used to evaluate the effects of compounds on gene expression in the cells. Most of the studies so far have analyzed the transcriptome of the cell. The basic assumption of this appro...

    Ritu Jain, Francis Doyle, Ajish D. George… in Microarray Methods for Drug Discovery (2010)

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    Bioinformatic Tools for Studying Post-Transcriptional Gene Regulation: The UAlbany TUTR Collection and Other Informatic Resources

    The untranslated regions (UTRs) of many mRNAs contain sequence and structural motifs that are used to regulate the stability, localization, and translatability of the mRNA. It should be possible to discover pr...

    Francis Doyle, Christopher Zaleski, Ajish D. George… in Post-Transcriptional Gene Regulation (2008)