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Open AccessLong-term effectiveness of benralizumab in severe eosinophilic asthma patients treated for 96-weeks: data from the ANANKE study
The efficacy of benralizumab has been broadly demonstrated in severe eosinophilic asthma (SEA), but only few real-life studies evaluated its long-term effects. Here we present novel data from the ANANKE study ...
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Article
Open AccessBronchial thermoplasty in severe asthma: a real-world study on efficacy and gene profiling
Bronchial thermoplasty (BT) is an effective treatment in severe asthma. How to select patients who more likely benefit from BT is an unmet clinical need. Moreover, mechanisms of BT efficacy are still largely u...
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Open AccessChAracterization of ItaliaN severe uncontrolled Asthmatic patieNts Key features when receiving Benralizumab in a real-life setting: the observational rEtrospective ANANKE study
Data from phase 3 trials have demonstrated the efficacy and safety of benralizumab in patients with severe eosinophilic asthma (SEA). We conducted a real-world study examining the baseline characteristics of a...
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Article
Open AccessNoninvasive respiratory support outside the intensive care unit for acute respiratory failure related to coronavirus-19 disease: a systematic review and meta-analysis
Noninvasive respiratory support (NIRS) has been diffusely employed outside the intensive care unit (ICU) to face the high request of ventilatory support due to the massive influx of patients with acute respira...
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Open AccessCorrection to: Atypical pathogens in hospitalized patients with community-acquired pneumonia: a worldwide perspective
An amendment to this paper has been published and can be accessed via the original article.
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Open AccessEfficacy of tocilizumab in patients with COVID-19 ARDS undergoing noninvasive ventilation
The severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is extremely variable, ranging from asymptomatic patients to those who develop severe acute respiratory distress syndrome ...
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Article
Open AccessUse of narrative medicine to identify key factors for effective doctor–patient relationships in severe asthma
In this project the authors use a narrative medicine (NM) approach to assess the promotion of trust in the relationship between physicians and their asthma patients.
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Article
Open AccessAtypical pathogens in hospitalized patients with community-acquired pneumonia: a worldwide perspective
Empirical antibiotic coverage for atypical pathogens in community-acquired pneumonia (CAP) has long been debated, mainly because of a lack of epidemiological data. We aimed to assess both testing for atypical ...
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Article
Open AccessAcute respiratory failure as presentation of late-onset Pompe disease complicating the diagnostic process as a labyrinth: a case report
Acute respiratory failure can be triggered by several causes, either of pulmonary or extra-pulmonary origin. Pompe disease, or type II glycogen storage disease, is a serious and often fatal disorder, due to a ...
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Article
Open AccessHeat-induced necrosis after bronchial thermoplasty: a new concern?
Bronchial thermoplasty (BT) is an endoscopic procedure for the treatment of severe refractory asthma, based on the local airways delivery of radio-frequency at 65 °C. Several controlled clinical studies demons...
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Article
Open AccessRecurrent lung atelectasis from fibrin plugs as a very early complication of bronchial thermoplasty: a case report
Bronchial thermoplasty (BT) is a new therapeutic option for severe refractory asthma not controlled despite high dose inhaled corticosteroids plus long-acting bronchodilators and omalizumab in selected cases. ...
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Article
Open AccessTailored therapy for severe asthma
Patients with severe asthma or COPD have often a suboptimal symptom control due to inadequate treatment. A better understanding of pathogenetic mechanisms, phenotypes, endotypes and the new technologies availa...
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Article
A Budget Impact Analysis of Bronchial Thermoplasty for Severe Asthma in Clinical Practice
Fully 80% of asthma-related deaths occur in patients with uncontrolled disease and 50% of all costs are attributable to this subgroup. Although asthma is costly, direct costs and loss of productivity have only...
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Article
Open Access“Neurologist's contribution to the diagnosis of sine materia respiratory insufficiency: case report”
Right-to-left shunt (RLS) may be the cause of marked hypoxemia, a respiratory insufficiency which is usually difficult to diagnose by respiratory physicians as it develops in the absence of an intrinsic lung d...
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Open AccessLong-term benefits of omalizumab in a patient with severe non-allergic asthma
Currently, omalizumab is indicated for the treatment of patients with severe allergic uncontrolled asthma despite optimal therapy.
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Open AccessEosinophilic infiltrate in a patient with severe Legionella pneumonia as a levofloxacin-related complication: a case report
Legionella pneumonia can appear with different levels of severity and it can often present with complications such as acute respiratory distress syndrome.
