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Article
Further explanations about the role of thyroid scintigraphy in the era of TIRADS
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Article
Open AccessPapillary thyroid carcinoma: ≤ 10 mm does not always mean pN0. A multicentric real-world study
The incidence of papillary thyroid carcinoma (PTC) is increasing and PTC ≤ 10 mm (PTMC) accounts for most new diagnoses. PTMCs are not always low risk, as detection of lymph nodes metastasis (LNM) may occur. T...
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Open AccessReappraising the role of thyroid scintigraphy in the era of TIRADS: A clinically-oriented viewpoint
Thyroid nodules (TNs) are a common entity, with the majority being benign. Therefore, employing an accurate rule-out strategy in clinical practice is essential. In the thyroid field, the current era is signifi...
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Article
Cinque anni di trattamento con GH ricombinante a somministrazione settimanale \(\mathit{vs}\) quotidiana. Estensione di uno studio di fase 2
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Open AccessPrevalence and significance of indeterminate calcitonin values in patients with thyroid nodules: A systematic review and meta-analysis
Although calcitonin (Ctn) measurement is recognized as the most accurate diagnostic test for medullary thyroid carcinoma (MTC), its routine execution is not universally accepted for several reasons, including ...
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Article
Open AccessNuove strategie di indagine delle linfoadenopatie nel carcinoma tiroideo
L’identificazione delle metastasi linfonodali è fondamentale nella gestione iniziale dei pazienti con noduli tiroidei sospetti, in quanto può modificare la tipologia dell’intervento chirurgico, e nella gestion...
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Open AccessAssociazione tra la sindrome metabolica e le caratteristiche clinico-patologiche del carcinoma papillifero tiroideo
Il progressivo incremento dell’incidenza di carcinoma papillifero tiroideo nella popolazione mondiale può essere solo in parte attribuito alla maggiore diffusione nella pratica clinica della diagnostica ecogra...
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Article
Open AccessAgonisti del recettore del GLP1 e infiammazione: non solo compenso glicemico
I farmaci agonisti del recettore del Glucagon-like peptide 1 (GLP1) sono ormai da diversi anni protagonisti nella gestione terapeutica del paziente affetto da diabete mellito tipo 2. Oltre alla significativa effi...
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Article
Onset of Marine-Lenhart syndrome and Graves’ ophthalmopathy in a female patient treated with alemtuzumab for multiple sclerosis
Immune checkpoint blockade therapy may lead to thyroid dysfunction in 3–7% of treated patients. Alemtuzumab is a CD52 inhibitor leading to thyroid dysfunction in approximately 40% of patients. A female patient...
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Article
Open AccessEndocrinopatie e anemie / anemie ed endocrinopatie: una si(pali)ndrome spesso misconosciuta
È comune osservazione nella pratica clinica che, spesso, i deficit endocrini si accompagnano ad anemie di vario grado. È anche noto che alcune specifiche anemie quali la talassemia possono essere associate a d...
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Article
Il ruolo della tireoglobulina ultrasensibile nel follow-up del carcinoma differenziato tiroideo
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Article
Validità dei sistemi di classificazione ecografica nell’identificare i noduli tiroidei da non sottoporre all’agoaspirato
La prevalenza dei noduli tiroidei nella popolazione generale è in continuo incremento, e per almeno la metà dei noduli sottoposti a FNA il risultato della citologia è benigno. I sistemi di classificazione ecog...
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Article
Selenium exerts protective effects against oxidative stress and cell damage in human thyrocytes and fibroblasts
Selenium, incorporated into specific seleno-enzymes, is essential to proper thyroid function and protect cells from oxidative damage induced by H2O2 during thyroid hormone synthesis. Several studies indicated tha...
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Article
Challenges in the treatment of parathyroid carcinoma: a case report
Parathyroid carcinoma (PC) is a rare neoplasm with a high rate of recurrence and an indolent course. It is frequently functional, causing nearly 1% of the cases of primary hyperparathyroidism (HPT), and in som...
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Article
Open AccessIRF5 promotes the proliferation of human thyroid cancer cells
Interferon Regulatory Factor 5 is a transcription factor that regulates the expression of genes involved in the response to viral infection and in the stimulation of the immune system. Moreover, multiple studi...
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Article
In thyroid cancer cell lines expression of periostin gene is controlled by p73 and is not related to epigenetic marks of active transcription
Periostin expression is a feature of the epithelial-mesenchymal transition, which occurs during cancer progression. Previous reports indicate that periostin expression is related to tumour aggressiveness.
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Article
IGF and Insulin Receptor Signaling in Breast Cancer
Major molecular abnormalities in breast cancer include the deregulation of several components of the IGF system. It is well recognized that the epithelial breast cancer cells commonly overexpress the IGF-I rec...
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Article
Tyrosine kinase inhibitor STI571 enhances thyroid cancer cell motile response to Hepatocyte Growth Factor
The Hepatocyte Growth Factor (HGF) and its receptor Met are physiological regulators of cell migration. HGF and Met have also been implicated in tumor progression and metastasis. We show here that the tyrosine...
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Article
Insulin receptor activation by IGF-II in breast cancers: evidence for a new autocrine/paracrine mechanism
IGF-II, produced by breast cancer epithelial and stromal cells, enhances tumor growth by activating the IGF-I receptor (IGF-I-R) via autocrine and paracrine mechanisms. Previously we found that the insulin rec...
