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Article
Open AccessThe prognostic value of patient-reported outcomes in allogeneic hematopoietic stem cell transplantation: exploratory analysis of a randomized nutrition intervention trial
Whether patient-reported outcomes (PROs) can predict overall survival (OS) and non-relapse mortality (NRM) among recipients of allogeneic stem cell transplantation (allo-HSCT), is unclear. We performed an expl...
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Article
Health-related quality of life profile of patients with immune thrombocytopenia in the real life is impaired by splenectomy
The impact of splenectomy on health-related quality of life (HRQoL) in patients with immune thrombocytopenia (ITP) remains scarcely explored. Therefore, we evaluated HRQoL with the 36-Item Short-Form Health Su...
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Article
The IPSS-R more accurately captures fatigue severity of newly diagnosed patients with myelodysplastic syndromes compared with the IPSS index
We aimed to compare fatigue of newly diagnosed patients with myelodysplastic syndromes (MDS) with that of the general population (GP). We also investigated the ability of the IPSS and IPSS-R to capture severit...
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Article
High serum ferritin levels in newly diagnosed patients with myelodysplastic syndromes are associated with greater symptom severity
We examined the association between serum ferritin (SF) levels and patient-reported functional aspects and symptoms, as measured by the EORTC QLQ-C30, in newly diagnosed patients with myelodysplastic syndromes...
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Article
Consistency matters: measurement invariance of the EORTC QLQ-C30 questionnaire in patients with hematologic malignancies
To ensure that observed differences in the scores of the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) reflect actual differences in health-r...
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Article
Health-related quality of life of newly diagnosed chronic myeloid leukemia patients treated with first-line dasatinib versus imatinib therapy
There is paucity of evidence-based data on health-related quality of life (HRQOL) outcomes of chronic myeloid leukemia (CML) patients treated with tyrosine kinase inhibitors (TKIs). We performed a multicenter ...
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Article
Open AccessPatient-reported outcomes in randomised clinical trials of bladder cancer: an updated systematic review
Despite international recommendations of including patient-reported outcomes (PROs) in randomised clinical trials (RCTs), a 2014 review concluded that few RCTs of bladder cancer (BC) report PRO as an outcome. ...
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Article
Health-related quality of life, symptom burden, and comorbidity in long-term survivors of acute promyelocytic leukemia
The objective of this study was to investigate health-related quality of life (HRQOL), symptom burden, and comorbidity profile in long-term acute promyelocytic leukemia (APL) survivors treated with standard ch...
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Article
Modeling strategies to improve parameter estimates in prognostic factors analyses with patient-reported outcomes in oncology
The inclusion of patient-reported outcome (PRO) questionnaires in prognostic factor analyses in oncology has substantially increased in recent years. We performed a simulation study to compare the performances...
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Article
Open AccessDistribution- and anchor-based methods to determine the minimally important difference on patient-reported outcome questionnaires in oncology: a structured review
Interpretation of differences or changes in patient-reported outcome scores should not only consider statistical significance, but also clinical relevance. Accordingly, accurate determination of the minimally ...
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Article
Open AccessA prospective observational study to assess clinical decision-making, prognosis, quality of life and satisfaction with care in patients with relapsed/refractory multiple myeloma: the CLARITY study protocol
Treatment decision-making in patients with relapsed/refractory multiple myeloma (RRMM) is challenging for a number of reasons including, the heterogeneity of disease at relapse and the number of possible thera...
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Article
Open AccessPhysicians’ attitude towards selection of second line therapy with nilotinib and dasatinib in chronic myeloid leukemia patients
We investigated factors that physicians consider of most importance in the selection of second line tyrosine kinase inhibitors treatments (TKIs) in chronic myeloid leukemia patients (CML).
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Article
Psychological well-being and social support in chronic myeloid leukemia patients receiving lifelong targeted therapies
The main objective of this study was to investigate whether social support is independently associated with psychological well-being in chronic myeloid leukemia (CML) patients. Secondary objectives were to com...