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  1. Article

    Open Access

    De novo DNA methyltransferase activity in colorectal cancer is directed towards H3K36me3 marked CpG islands

    The aberrant gain of DNA methylation at CpG islands is frequently observed in colorectal tumours and may silence the expression of tumour suppressors such as MLH1. Current models propose that these CpG islands ar...

    Roza H. Ali Masalmeh, Francesca Taglini, Cristina Rubio-Ramon… in Nature Communications (2021)

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  2. No Access

    Article

    Gain-of-function DNMT3A mutations cause microcephalic dwarfism and hypermethylation of Polycomb-regulated regions

    DNA methylation and Polycomb are key factors in the establishment of vertebrate cellular identity and fate. Here we report de novo missense mutations in DNMT3A, which encodes the DNA methyltransferase DNMT3A. The...

    Patricia Heyn, Clare V. Logan, Adeline Fluteau, Rachel C. Challis… in Nature Genetics (2019)