9 Result(s)

Article

Plasma neuregulin 1 as a synaptic biomarker in Alzheimer’s disease: a discovery cohort study

Synaptic dysfunction is an early core feature of Alzheimer’s disease (AD), closely associated with cognitive symptoms. Neuregulin 1 (NRG1) is a growth and differentiation factor with a key role in the developm...

Agathe Vrillon, François Mouton-Liger, Matthieu Martinet… in Alzheimer's Research & Therapy (2022)

Article

CSF levels of the BACE1 substrate NRG1 correlate with cognition in Alzheimer’s disease

The presynaptic protein neuregulin1 (NRG1) is cleaved by beta-site APP cleaving enzyme 1 (BACE1) in a similar way as amyloid precursor protein (APP) NRG1 can activate post-synaptic receptor tyrosine-protein ki...

François Mouton-Liger, Julien Dumurgier, Emmanuel Cognat… in Alzheimer's Research & Therapy (2020)

Article

Are ketogenic diets promising for Alzheimer’s disease? A translational review

Brain amyloid deposition and neurofibrillary tangles in Alzheimer’s disease (AD) are associated with complex neuroinflammatory reactions such as microglial activation and cytokine production. Glucose metabolis...

Matthieu Lilamand, Baptiste Porte, Emmanuel Cognat… in Alzheimer's Research & Therapy (2020)

Article

PKR involvement in Alzheimer’s disease

Brain lesions in Alzheimer’s disease (AD) are characterized by Aβ accumulation, neurofibrillary tangles, and synaptic and neuronal vanishing. According to the amyloid cascade hypothesis, Aβ1-42 oligomers could...

Jacques Hugon, François Mouton-Liger, Julien Dumurgier… in Alzheimer's Research & Therapy (2017)

Article

Utility of CSF biomarkers in psychiatric disorders: a national multicentre prospective study

Affective and psychotic disorders are mental or behavioural patterns resulting in an inability to cope with life’s ordinary demands and routines. These conditions can be a prodromal event of Alzheimer’s diseas...

Claire Paquet, Eloi Magnin, David Wallon… in Alzheimer's Research & Therapy (2016)

Article

Neuroinflammation and Aβ Accumulation Linked To Systemic Inflammation Are Decreased By Genetic PKR Down-Regulation

Alzheimer's disease (AD) is a neurodegenerative disorder, marked by senile plaques composed of amyloid-β (Aβ) peptide, neurofibrillary tangles, neuronal loss and neuroinflammation. Previous works have suggeste...

Anne-Sophie Carret-Rebillat, Clarisse Pace, Sarah Gourmaud… in Scientific Reports (2015)

Article

Neuroprotective role of PKR in a model of neurodegeneration due to mild impairment of oxidative metabolism

François Mouton-Liger, Anne-Sophie Rebillat, Sarah Gourmaud… in Molecular Neurodegeneration (2013)

Article

Peripheral inflammation increases PKR activation, Tau phosphorylation and amyloid β production in wild-type mice

François Mouton-Liger, Anne-Sophie Rebillat, Clarisse Pace… in Molecular Neurodegeneration (2013)