21 Result(s)
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Initiation of continuous renal replacement therapy versus intermittent hemodialysis in critically ill patients with severe acute kidney injury: a secondary analysis of STARRT-AKI trial
There is controversy regarding the optimal renal-replacement therapy (RRT) modality for critically ill patients with acute kidney injury (AKI).
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Coronavirus disease 2019
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Automated APACHE II and SOFA score calculation using real-world electronic medical record data in a single center
The integration of illness severity and organ dysfunction scores into clinical practice, including the APACHE II and SOFA scores, has been challenging due to constraints associated to manual score calculation....
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Vitamin C in sepsis
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Unclear reporting of secondary outcome in randomized trial of Lv et al
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Open AccessResearch interrupted: applying the CONSERVE 2021 Statement to a randomized trial of rehabilitation during critical illness affected by the COVID-19 pandemic
The COVID-19 pandemic disrupted non-COVID critical care trials globally as intensive care units (ICUs) prioritized patient care and COVID-specific research. The international randomized controlled trial CYCLE (Cr...
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Open AccessA Bayesian reanalysis of the Standard versus Accelerated Initiation of Renal-Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial
Timing of initiation of kidney-replacement therapy (KRT) in critically ill patients remains controversial. The Standard versus Accelerated Initiation of Renal-Replacement Therapy in Acute Kidney Injury (STARRT-AK...
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Open AccessThe evolution of mean arterial pressure in critically ill patients on vasopressors before and during a trial comparing a specific mean arterial pressure target to usual care
In randomized clinical controlled trials, the choice of usual care as the comparator may be associated with better clinician uptake of the study protocol and lead to more generalizable results. However, if car...
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Open AccessHigh-dose vitamin-C induced prolonged factitious hyperglycemia in a peritoneal dialysis patient: a case report
High-dose vitamin C is increasingly used for sepsis and more recently for coronavirus disease 2019 (COVID-19) infections. Proponents argue that the low cost and near perfect safety profile of vitamin C support...
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Corticosteroids in COVID-19 and non-COVID-19 ARDS: a systematic review and meta-analysis
Corticosteroids are now recommended for patients with severe COVID-19 including those with COVID-related ARDS. This has generated renewed interest regarding whether corticosteroids should be used in non-COVID ...
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Open AccessLessening Organ dysfunction with VITamin C (LOVIT): protocol for a randomized controlled trial
Sepsis is a health problem of global importance; treatments focus on controlling infection and supporting failing organs. Recent clinical research suggests that intravenous vitamin C may decrease mortality in ...
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The harm of high-frequency oscillatory ventilation (HFOV) in ARDS is not related to a high baseline risk of acute cor pulmonale or short-term changes in hemodynamics
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Open AccessAnti-Ebola therapy for patients with Ebola virus disease: a systematic review
Management of Ebola virus disease (EVD) has historically focused on infection prevention, case detection and supportive care. Several specific anti-Ebola therapies have been investigated, including during the ...
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Open AccessFluid sparing and norepinephrine use in a rat model of resuscitated haemorrhagic shock: end-organ impact
Haemostasis and correction of hypovolemia are the pillars of early haemorrhage shock (HS) management. Vasopressors, which are not recommended as first-line therapy, are an alternative to aggressive fluid resus...
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Target blood pressure for septic and vasodilatory shock: what is optimal?
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Pooled analysis of higher versus lower blood pressure targets for vasopressor therapy septic and vasodilatory shock
Guidelines for shock recommend mean arterial pressure (MAP) targets for vasopressor therapy of at least 65 mmHg and, until recently, suggested that patients with underlying chronic hypertension and atheroscler...
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Open AccessPharmacological interventions for agitation in patients with traumatic brain injury: protocol for a systematic review and meta-analysis
Traumatic brain injury (TBI) is a worldwide leading cause of mortality and disability. Among TBI complications, agitation is a frequent behavioural problem. Agitation causes potential harm to patients and care...
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Open AccessWhen to start renal replacement therapy in critically ill patients with acute kidney injury: comment on AKIKI and ELAIN
The dilemma of whether and when to start renal replacement therapy among critically ill patients with acute kidney injury in the absence of conventional indications has long been a vexing challenge for clinici...
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Higher versus lower blood pressure targets for vasopressor therapy in shock: a multicentre pilot randomized controlled trial
In shock, hypotension may contribute to inadequate oxygen delivery, organ failure and death. We conducted the Optimal Vasopressor Titration (OVATION) pilot trial to inform the design of a larger trial examinin...
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Open AccessThe influence of corticosteroid treatment on the outcome of influenza A(H1N1pdm09)-related critical illness
Patients with 2009 pandemic influenza A(H1N1pdm09)-related critical illness were frequently treated with systemic corticosteroids. While observational studies have reported significant corticosteroid-associate...
