6 Result(s)

Article

Molecular complete remission following combination treatment of daratumumab and venetoclax in an adolescent with relapsed mixed phenotype acute leukemia

Martin Stanulla, Denis M. Schewe, Beat Bornhauser… in Annals of Hematology (2023)

Article

Isocitrate dehydrogenase 1 mutation drives leukemogenesis by PDGFRA activation due to insulator disruption in acute myeloid leukemia (AML)

Acute myeloid leukemia (AML) is characterized by complex molecular alterations and driver mutations. Elderly patients show increased frequencies of IDH mutations with high chemoresistance and relapse rates despit...

Sophie Steinhäuser, Patricia Silva, Lennart Lenk, Thomas Beder, Alina Hartmann… in Leukemia (2023)

Article

CD79a promotes CNS-infiltration and leukemia engraftment in pediatric B-cell precursor acute lymphoblastic leukemia

Central nervous system (CNS) involvement remains a challenge in the diagnosis and treatment of acute lymphoblastic leukemia (ALL). In this study, we identify CD79a (also known as Igα), a signaling component of...

Lennart Lenk, Michela Carlet, Fotini Vogiatzi, Lea Spory… in Communications Biology (2021)

Article

Synergism between IL7R and CXCR4 drives BCR-ABL induced transformation in Philadelphia chromosome-positive acute lymphoblastic leukemia

Ph⁺ acute lymphoblastic leukemia (ALL) is characterized by the expression of an oncogenic fusion kinase termed BCR-ABL1. Here, we show that interleukin 7 receptor (IL7R) interacts with the chemokine receptor CXCR...

Hend Abdelrasoul, Anila Vadakumchery, Markus Werner, Lennart Lenk… in Nature Communications (2020)

Article

Monitoring the dynamics of clonal tumour evolution in vivo using secreted luciferases

Tumours are heterogeneous cell populations that undergo clonal evolution during tumour progression, metastasis and response to therapy. Short hairpin RNAs (shRNAs) generate stable loss-of-function phenotypes a...

Joël P. Charles, Jeannette Fuchs, Mirjam Hefter… in Nature Communications (2014)

Article

Malignant transformation in a defined genetic background: proteome changes displayed by 2D-PAGE

Cancer arises from normal cells through the stepwise accumulation of genetic alterations. Cancer development can be studied by direct genetic manipulation within experimental models of tumorigenesis. Thereby, ...

Stephanie M Pütz, Fotini Vogiatzi, Thorsten Stiewe, Albert Sickmann in Molecular Cancer (2010)