18 Result(s)
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Florian Kuchenbauer
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Article
Open AccessRedefining high risk multiple myeloma with an APOBEC/Inflammation-based classifier
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Article
Open AccessTranslation efficiency driven by CNOT3 subunit of the CCR4-NOT complex promotes leukemogenesis
Protein synthesis is frequently deregulated during tumorigenesis. However, the precise contexts of selective translational control and the regulators of such mechanisms in cancer is poorly understood. Here, we...
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Open AccessElucidating the importance and regulation of key enhancers for human MEIS1 expression
Myeloid ecotropic virus insertion site 1 (MEIS1) is essential for normal hematopoiesis and is a critical factor in the pathogenesis of a large subset of acute myeloid leukemia (AML). Despite the clinical relev...
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Chapter
The Role of Stem Cell Transplant in the Therapy of Acute Myeloid Leukemia (AML)
Acute myeloid leukemia (AML) is the most common indication for allogeneic hematopoietic stem cell transplant (HSCT). Decision-making around allogeneic HSCT for AML patients in first remission should be based o...
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Article
MicroRNA-708 is a novel regulator of the Hoxa9 program in myeloid cells
MicroRNAs (miRNAs) are commonly deregulated in acute myeloid leukemia (AML), affecting critical genes not only through direct targeting, but also through modulation of downstream effectors. Homeobox (Hox) genes b...
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Lipid nanoparticle-mediated siRNA delivery for safe targeting of human CML in vivo
Efficient and safe delivery of siRNA in vivo is the biggest roadblock to clinical translation of RNA interference (RNAi)-based therapeutics. To date, lipid nanoparticles (LNPs) have shown efficient delivery of...
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Revisiting thrombocytopenia in acute promyelocytic leukemia
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Erratum: Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells
Nat. Med. 24, 282–291 (2018); published online 12 February 2018; corrected after print 6 March 2018 In the version of this article initially published, Omid Shah's name was misspelled as Omid Sha. The error ha...
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Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells
Combining the kinase inhibitor sorafenib with allogeneic stem cell transplantation boosts immune responses against a subtype of acute myelogenous leukemia, suggesting potential clinical benefit.
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Article
Open AccessThe non-coding RNA landscape of human hematopoiesis and leukemia
Non-coding RNAs have emerged as crucial regulators of gene expression and cell fate decisions. However, their expression patterns and regulatory functions during normal and malignant human hematopoiesis are in...
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In Vivo Processing Assay Based on a Dual-Luciferase Reporter System to Evaluate DROSHA Enzymatic Activity
Luciferase reporter assays are widely used to study promoter activity, transcription factors, intracellular signaling, protein interactions (Jia et al., PloS One 6:e26414), miRNA processing (Allegra and Merten...
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Article
The Lin28b–let-7–Hmga2 axis determines the higher self-renewal potential of fetal haematopoietic stem cells
Mouse haematopoietic stem cells (HSCs) undergo a postnatal transition in several properties, including a marked reduction in their self-renewal activity. We now show that the developmentally timed change in th...
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Impact of serum storage conditions on microRNA stability
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Article
Circulating microRNAs as biomarkers - True Blood?
MicroRNAs are post-transcriptional regulators that are involved in many physiological and pathophysiological conditions. A recent study compared the expression profiles of hundreds of blood-borne microRNAs acr...
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Chapter
MicroRNAs in Leukemia
Deregulated gene expression plays a crucial role in leukemia and recent evidence suggests that in hematologic malignancies deregulated microRNAs (miRNAs) have the ability to function as both tumor suppressor a...
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Article
Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
Marco Marra and colleagues identify somatic mutations in EZH2 in diffuse large B-cell lymphomas and follicular lymphomas. EZH2 is a histone methyltransferase that participates in trimethylation of H3 Lys27 (H3K27...
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Article
Identification of miR-145 and miR-146a as mediators of the 5q– syndrome phenotype
For myelodysplastic syndromes caused by deletion of chromosome 5q, Daniel Starczynowski et al. provide evidence that decreased expression of two miRNAs in this region—miR-145 and miR-146a—contributes to abnormal ...
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Article
MiRNAs, epigenetics, and cancer
By virtue of having multiple targets, a microRNA (miRNA) can have variable effects on oncogenesis by acting as tumor suppressor or oncogene in a context-dependent manner. Genome-wide epigenetic changes that oc...
