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Article
Open AccessCell shape sensing licenses dendritic cells for homeostatic migration to lymph nodes
Immune cells experience large cell shape changes during environmental patrolling because of the physical constraints that they encounter while migrating through tissues. These cells can adapt to such deformati...
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Article
Open AccessSopa: a technology-invariant pipeline for analyses of image-based spatial omics
Spatial omics data allow in-depth analysis of tissue architectures, opening new opportunities for biological discovery. In particular, imaging techniques offer single-cell resolutions, providing essential insi...
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Article
Open AccessSpatially-resolved transcriptomics reveal macrophage heterogeneity and prognostic significance in diffuse large B-cell lymphoma
Macrophages are abundant immune cells in the microenvironment of diffuse large B-cell lymphoma (DLBCL). Macrophage estimation by immunohistochemistry shows varying prognostic significance across studies in DLB...
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Open AccessCebp1 and Cebpβ transcriptional axis controls eosinophilopoiesis in zebrafish
Eosinophils are a group of granulocytes well known for their capacity to protect the host from parasites and regulate immune function. Diverse biological roles for eosinophils have been increasingly identified...
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Article
Open AccessContribution of circulating monocytes in maintaining homeostasis of resident macrophages in postnatal and young adult mouse cochlea
The percentage of macrophage subpopulations based on their origins in the adult cochlea remains unclear. This study aimed to elucidate the origins of cochlear macrophages during the onset phase and development...
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Article
Open AccessBrain macrophage development, diversity and dysregulation in health and disease
Brain macrophages include microglia in the parenchyma, border-associated macrophages in the meningeal-choroid plexus-perivascular space, and monocyte-derived macrophages that infiltrate the brain under various...
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Article
Open AccessRoles of macrophages in tumor development: a spatiotemporal perspective
Macrophages are critical regulators of tissue homeostasis but are also abundant in the tumor microenvironment (TME). In both primary tumors and metastases, such tumor-associated macrophages (TAMs) seem to supp...
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Article
Open AccessSingle-cell analyses implicate ascites in remodeling the ecosystems of primary and metastatic tumors in ovarian cancer
Ovarian cancer (OC) is an aggressive gynecological tumor usually diagnosed with widespread metastases and ascites. Here, we depicted a single-cell landscape of the OC ecosystem with five tumor-relevant sites, ...
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Article
Open AccessLactation-associated macrophages exist in murine mammary tissue and human milk
Macrophages are involved in immune defense, organogenesis and tissue homeostasis. Macrophages contribute to the different phases of mammary gland remodeling during development, pregnancy and involution postlac...
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Article
Open AccessMaternal dendritic cells influence fetal allograft response following murine in-utero hematopoietic stem cell transplantation
Intrauterine hematopoietic stem cell transplantation (IUT), potentially curative in congenital haematological disease, is often inhibited by deleterious immune responses to donor cells resulting in subtherapeu...
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Article
Open AccessMafB-restricted local monocyte proliferation precedes lung interstitial macrophage differentiation
Resident tissue macrophages (RTMs) are differentiated immune cells that populate distinct niches and exert important tissue-supportive functions. RTM maintenance is thought to rely either on differentiation fr...
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Article
Open AccessOxidized mitochondrial DNA induces gasdermin D oligomerization in systemic lupus erythematosus
Although extracellular DNA is known to form immune complexes (ICs) with autoantibodies in systemic lupus erythematosus (SLE), the mechanisms leading to the release of DNA from cells remain poorly characterized...
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Article
Open AccessIdentification of distinct functional thymic programming of fetal and pediatric human γδ thymocytes via single-cell analysis
Developmental thymic waves of innate-like and adaptive-like γδ T cells have been described, but the current understanding of γδ T cell development is mainly limited to mouse models. Here, we combine single cel...
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Open AccessSingle-cell transcriptomics and surface epitope detection in human brain epileptic lesions identifies pro-inflammatory signaling
Epileptogenic triggers are multifactorial and not well understood. Here we aimed to address the hypothesis that inappropriate pro-inflammatory mechanisms contribute to the pathogenesis of refractory epilepsy (...
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Open AccessInfection of lung megakaryocytes and platelets by SARS-CoV-2 anticipate fatal COVID-19
SARS-CoV-2, although not being a circulatory virus, spread from the respiratory tract resulting in multiorgan failures and thrombotic complications, the hallmarks of fatal COVID-19. A convergent contributor co...
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Open AccessSingle-cell and spatial analysis reveal interaction of FAP+ fibroblasts and SPP1+ macrophages in colorectal cancer
Colorectal cancer (CRC) is among the most common malignancies with limited treatments other than surgery. The tumor microenvironment (TME) profiling enables the discovery of potential therapeutic targets. Here...
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Article
Open AccessTwin study reveals non-heritable immune perturbations in multiple sclerosis
Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system underpinned by partially understood genetic risk factors and environmental triggers and their undefined interactions1,2. He...
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Open AccessProlonged SARS-CoV-2 RNA virus shedding and lymphopenia are hallmarks of COVID-19 in cancer patients with poor prognosis
Patients with cancer are at higher risk of severe coronavirus infectious disease 2019 (COVID-19), but the mechanisms underlying virus–host interactions during cancer therapies remain elusive. When comparing na...
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Article
Repositioning TH cell polarization from single cytokines to complex help
When helper T (TH) cell polarization was initially described three decades ago, the TH cell universe grew dramatically. New subsets were described based on their expression of few specific cytokines. Beyond TH1 a...
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Article
Open AccessDysregulated hematopoiesis in bone marrow marks severe COVID-19
Severe coronavirus disease 2019 (COVID-19) is often indicated by lymphopenia and increased myelopoiesis; however, the underlying mechanism is still unclear, especially the alteration of hematopoiesis. It is im...
