48 Result(s)
within
Florent Ginhoux
Biomedicine
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Article
Multicellular tumor spheroid model to study the multifaceted role of tumor-associated macrophages in PDAC
While considerable efforts have been made to develop new therapies, progress in the treatment of pancreatic cancer has so far fallen short of patients’ expectations. This is due in part to the lack of predicti...
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Defining myeloid-derived suppressor cells
Myeloid-derived suppressor cells (MDSCs) are cells of neutrophil and monocyte lineages with potent immunosuppressive activity. Numerous studies in mice and humans have identified important roles for MDSCs in s...
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Open AccessCell shape sensing licenses dendritic cells for homeostatic migration to lymph nodes
Immune cells experience large cell shape changes during environmental patrolling because of the physical constraints that they encounter while migrating through tissues. These cells can adapt to such deformati...
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Open AccessBrain macrophage development, diversity and dysregulation in health and disease
Brain macrophages include microglia in the parenchyma, border-associated macrophages in the meningeal-choroid plexus-perivascular space, and monocyte-derived macrophages that infiltrate the brain under various...
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Open AccessRoles of macrophages in tumor development: a spatiotemporal perspective
Macrophages are critical regulators of tissue homeostasis but are also abundant in the tumor microenvironment (TME). In both primary tumors and metastases, such tumor-associated macrophages (TAMs) seem to supp...
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Open AccessLactation-associated macrophages exist in murine mammary tissue and human milk
Macrophages are involved in immune defense, organogenesis and tissue homeostasis. Macrophages contribute to the different phases of mammary gland remodeling during development, pregnancy and involution postlac...
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Reply to ‘Reclassification of plasmacytoid dendritic cells as innate lymphocytes is premature’
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Open AccessMafB-restricted local monocyte proliferation precedes lung interstitial macrophage differentiation
Resident tissue macrophages (RTMs) are differentiated immune cells that populate distinct niches and exert important tissue-supportive functions. RTM maintenance is thought to rely either on differentiation fr...
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Reclassifying plasmacytoid dendritic cells as innate lymphocytes
With respect to their ontogeny, emerging data support a lymphoid origin of plasmacytoid dendritic cells (pDCs), which seem to share a developmental trajectory with B cells. By contrast, conventional dendritic ...
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New perspectives on the origins and heterogeneity of mast cells
Mast cells are immune cells of the haematopoietic lineage that are now thought to have multifaceted functions during homeostasis and in various disease states. Furthermore, while mast cells have been known for...
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Oncofetal reprogramming in tumour development and progression
Embryonic development is characterized by rapidly dividing cells, cellular plasticity and a highly vascular microenvironment. These features are similar to those of tumour tissue, in that malignant cells are c...
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Open AccessSingle-cell transcriptomics and surface epitope detection in human brain epileptic lesions identifies pro-inflammatory signaling
Epileptogenic triggers are multifactorial and not well understood. Here we aimed to address the hypothesis that inappropriate pro-inflammatory mechanisms contribute to the pathogenesis of refractory epilepsy (...
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Reply to ‘Comment on: Repositioning TH cell polarization from single cytokines to complex help’
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Expanding dendritic cell nomenclature in the single-cell era
Single-cell technologies have enabled extensive profiling studies of human and mouse tissues and the identification of an ever-growing number of transcriptional clusters within the dendritic cell (DC) lineage....
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IFNγ and GM-CSF control complementary differentiation programs in the monocyte-to-phagocyte transition during neuroinflammation
During inflammation, Ly6Chi monocytes are rapidly mobilized from the bone marrow (BM) and are recruited into inflamed tissues, where they undergo monocyte-to-phagocyte transition (MTPT). The in vivo developmental...
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Repositioning TH cell polarization from single cytokines to complex help
When helper T (TH) cell polarization was initially described three decades ago, the TH cell universe grew dramatically. New subsets were described based on their expression of few specific cytokines. Beyond TH1 a...
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Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity
Tissue-resident memory T (TRM) cells are non-recirculating cells that exist throughout the body. Although TRM cells in various organs rely on common transcriptional networks to establish tissue residency, locatio...
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A single-cell and spatially resolved atlas of human breast cancers
Breast cancers are complex cellular ecosystems where heterotypic interactions play central roles in disease progression and response to therapy. However, our knowledge of their cellular composition and organiz...
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Embryonic macrophages function during early life to determine invariant natural killer T cell levels at barrier surfaces
It is increasingly recognized that immune development within mucosal tissues is under the control of environmental factors during early life. However, the cellular mechanisms that underlie such temporally and ...
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Genetic models of human and mouse dendritic cell development and function
Dendritic cells (DCs) develop in the bone marrow from haematopoietic progenitors that have numerous shared characteristics between mice and humans. Human counterparts of mouse DC progenitors have been identifi...
