11 Result(s)
within
Florent Ginhoux
Biomedicine
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Article
Open AccessCell shape sensing licenses dendritic cells for homeostatic migration to lymph nodes
Immune cells experience large cell shape changes during environmental patrolling because of the physical constraints that they encounter while migrating through tissues. These cells can adapt to such deformati...
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Article
Open AccessBrain macrophage development, diversity and dysregulation in health and disease
Brain macrophages include microglia in the parenchyma, border-associated macrophages in the meningeal-choroid plexus-perivascular space, and monocyte-derived macrophages that infiltrate the brain under various...
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Article
Open AccessRoles of macrophages in tumor development: a spatiotemporal perspective
Macrophages are critical regulators of tissue homeostasis but are also abundant in the tumor microenvironment (TME). In both primary tumors and metastases, such tumor-associated macrophages (TAMs) seem to supp...
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Open AccessLactation-associated macrophages exist in murine mammary tissue and human milk
Macrophages are involved in immune defense, organogenesis and tissue homeostasis. Macrophages contribute to the different phases of mammary gland remodeling during development, pregnancy and involution postlac...
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Article
Open AccessMafB-restricted local monocyte proliferation precedes lung interstitial macrophage differentiation
Resident tissue macrophages (RTMs) are differentiated immune cells that populate distinct niches and exert important tissue-supportive functions. RTM maintenance is thought to rely either on differentiation fr...
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Open AccessSingle-cell transcriptomics and surface epitope detection in human brain epileptic lesions identifies pro-inflammatory signaling
Epileptogenic triggers are multifactorial and not well understood. Here we aimed to address the hypothesis that inappropriate pro-inflammatory mechanisms contribute to the pathogenesis of refractory epilepsy (...
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Article
Repositioning TH cell polarization from single cytokines to complex help
When helper T (TH) cell polarization was initially described three decades ago, the TH cell universe grew dramatically. New subsets were described based on their expression of few specific cytokines. Beyond TH1 a...
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Publisher Correction: Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction
In the version of this article initially published, the equal contribution of the third author was omitted. The footnote links for that author should be “Sara Nejat1,11” and the correct statement is as follows: “
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Publisher Correction: Studying tissue macrophages in vitro: are iPSC-derived cells the answer?
In the original Figure 1, an arrow was mistakenly added between the fetal liver monocytes and the short-term and long-term HSCs. This arrow has now been removed.
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Article
New beginnings
Florent Ginhoux reflects on a 2002 paper by Merad and colleagues that challenged the dogma that adult Langerhans cells arise from blood-circulating precursors.
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Article
Dendritic cells and the malaria pre-erythrocytic stage
Malaria remains one of the main infectious diseases in intertropical regions. The malaria parasite has a complex life cycle in its mammalian host, switching between variable forms as it traverses through diffe...
