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  1. No Access

    Article

    cFLIP suppression and DR5 activation sensitize senescent cancer cells to senolysis

    Senolytics, drugs that kill senescent cells, have been proposed to improve the response to pro-senescence cancer therapies; however, this remains challenging due to a lack of broadly acting senolytic drugs. Us...

    Liqin Wang, Haojie **, Fleur Jochems, Siying Wang, Cor Lieftink… in Nature Cancer (2022)

  2. No Access

    Article

    EGFR activation limits the response of liver cancer to lenvatinib

    Hepatocellular carcinoma (HCC)—the most common form of liver cancer—is an aggressive malignancy with few effective treatment options1. Lenvatinib is a small-molecule inhibitor of multiple receptor tyrosine kinase...

    Haojie **, Yao** Shi, Yuanyuan Lv, Shengxian Yuan, Christel F. A. Ramirez… in Nature (2021)

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    Article

    Inducing and exploiting vulnerabilities for the treatment of liver cancer

    Liver cancer remains difficult to treat, owing to a paucity of drugs that target critical dependencies1,2; broad-spectrum kinase inhibitors such as sorafenib provide only a modest benefit to patients with hepatoc...

    Cun Wang, Serena Vegna, Haojie **, Bente Benedict, Cor Lieftink… in Nature (2019)