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Open AccessBlimp-1 and c-Maf regulate immune gene networks to protect against distinct pathways of pathobiont-induced colitis
Intestinal immune responses to microbes are controlled by the cytokine IL-10 to avoid immune pathology. Here, we use single-cell RNA sequencing of colon lamina propria leukocytes (LPLs) along with RNA-seq and ...
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Open AccessImmune microniches shape intestinal Treg function
The intestinal immune system is highly adapted to maintaining tolerance to the commensal microbiota and self-antigens while defending against invading pathogens1,2. Recognizing how the diverse network of local ce...
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Open AccessA conserved population of MHC II-restricted, innate-like, commensal-reactive T cells in the gut of humans and mice
Interactions with commensal microbes shape host immunity on multiple levels and play a pivotal role in human health and disease. Tissue-dwelling, antigen-specific T cells are poised to respond to local insults...
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Don Mason (1934–2021)
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Open AccessAccurate identification and quantification of commensal microbiota bound by host immunoglobulins
Identifying which taxa are targeted by immunoglobulins can uncover important host-microbe interactions. Immunoglobulin binding of commensal taxa can be assayed by sorting bound bacteria from samples and using ...
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Article
Host–microbiota maladaptation in colorectal cancer
Colorectal cancer (CRC) is a heterogeneous disease of the intestinal epithelium that is characterized by the accumulation of mutations and a dysregulated immune response. Up to 90% of disease risk is thought t...
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High-throughput phenoty** reveals expansive genetic and structural underpinnings of immune variation
By develo** a high-density murine immunophenoty** platform compatible with high-throughput genetic screening, we have established profound contributions of genetics and structure to immune variation ( ...
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Regulatory T cell adaptation in the intestine and skin
The intestine and skin are distinct microenvironments with unique physiological functions and are continually exposed to diverse environmental challenges. Host adaptation at these sites is an active process th...
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Author Correction: Pathogenic stromal cells as therapeutic targets in joint inflammation
In the originally published version of this article, the acknowledgements and affiliations contained errors. In the acknowledgements, “NIHR Oxford and Birmingham Biomedical Research Centres” and “the Departmen...
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Pathogenic stromal cells as therapeutic targets in joint inflammation
Knowledge of how the joint functions as an integrated unit in health and disease requires an understanding of the stromal cells populating the joint mesenchyme, including fibroblasts, tissue-resident macrophag...
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Open AccessAlpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis
Inflammatory bowel disease (IBD) are heterogenous disorders of the gastrointestinal tract caused by a spectrum of genetic and environmental factors. In mice, overlap** regions of chromosome 3 have been assoc...
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Erratum: Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor–neutralizing therapy in patients with inflammatory bowel disease
Nat. Med.; 10.1038/nm.4307; corrected online 11 April 2017 In the version of this article initially published, there were two typographical errors in the Abstract. The unnecessary 'h' in the line “Furthermore,...
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Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor–neutralizing therapy in patients with inflammatory bowel disease
The cytokine oncostatin M drives intestinal inflammation in mice, and its abundance in the intestine of patients with inflammatory bowel disease predicts response to tumor necrosis factor–neutralizing therapy.
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Open AccessT-bet is a key modulator of IL-23-driven pathogenic CD4+ T cell responses in the intestine
IL-23 is a key driver of pathogenic Th17 cell responses. It has been suggested that the transcription factor T-bet is required to facilitate IL-23-driven pathogenic effector functions; however, the precise rol...
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Open AccessIntegrative Phosphoproteomics Links IL-23R Signaling with Metabolic Adaptation in Lymphocytes
Interleukin (IL)-23 mediated signal transduction represents a major molecular mechanism underlying the pathology of inflammatory bowel disease, Crohn’s disease and ulcerative colitis. In addition, emerging evi...
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Emerging cytokine networks in colorectal cancer
Cytokine networks are key aspects of tumour immunology, particularly for colorectal cancer (CRC), for which inflammation and antitumour immunity are critical d...
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Open AccessTranscriptional profiling of macrophages derived from monocytes and iPS cells identifies a conserved response to LPS and novel alternative transcription
Macrophages differentiated from human induced pluripotent stem cells (IPSDMs) are a potentially valuable new tool for linking genotype to phenotype in functional studies. However, at a genome-wide level these ...
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Factors influencing success of clinical genome sequencing across a broad spectrum of disorders
Gilean McVean and colleagues report the results of a large-scale clinical genome sequencing project spanning a broad spectrum of disorders. They identify factors influencing successful genetic diagnosis and hi...
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The alarmin IL-33 promotes regulatory T-cell function in the intestine
The alarmin interleukin-33 is constitutively expressed at barrier sites and released in response to tissue damage; here, the IL-33 receptor ST2 is shown to be preferentially expressed on colonic regulatory T c...
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Innate lymphoid cells — a proposal for uniform nomenclature
Innate lymphoid cells (ILCs) have key roles in immune responses, lymphoid tissue development and tissue regeneration. Recently, several new ILC subsets were identified. Here, the authors propose the use of a u...
