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Article
Open AccessCharacterizing microfluidic approaches for a fast and efficient reagent exchange in single-molecule studies
Single-molecule experiments usually take place in flow cells. This experimental approach is essential for experiments requiring a liquid environment, but is also useful to allow the exchange of reagents before...
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Protocol
High-Resolution Atomic Force Microscopy Imaging of Nucleic Acids
Exploring the limits of spatial resolution has been a constant in the history of atomic force microscopy imaging. Since its invention in 1986, the AFM has beaten the barrier of resolution continuously, thanks ...
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Article
Open AccessTubZ filament assembly dynamics requires the flexible C-terminal tail
Cytomotive filaments are essential for the spatial organization in cells, showing a dynamic behavior based on nucleotide hydrolysis. TubZ is a tubulin-like protein that functions in extrachromosomal DNA moveme...
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Article
High flexibility of DNA on short length scales probed by atomic force microscopy
The mechanics of DNA bending on intermediate length scales (5–100 nm) plays a key role in many cellular processes, and is also important in the fabrication of artificial DNA structures, but previous experiment...
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Article
Mesoscale conformational changes in the DNA-repair complex Rad50/Mre11/Nbs1 upon binding DNA
Atherosclerotic plaques form when blood flow is disturbed and unusual patterns of mechanical stress are applied to the blood vessel wall. The endothelial cells lining these vessels play an important role in th...