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Article
Physicochemical Characterization of Berberine-loaded Pluronic F127 Polymeric Micelles and In Vivo Evaluation of Hypoglycemic Effect
In this study, a polymer micelle containing berberine (Ber) was prepared. The micelle was composed of Pluronic F127 and Ber. The hypoglycemic effect was verified by animal experiments.
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Article
Open AccessIncreased levels of conjugated bile acids are associated with human bile reflux gastritis
Bile acids (BAs) play essential roles in facilitating lipid digestion and absorption in the intestine. Gastric BAs were attributed to abnormal refluxing from duodenal compartments and correlated with the occur...
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Article
Open AccessTheabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism
Pu-erh tea displays cholesterol-lowering properties, but the underlying mechanism has not been elucidated. Theabrownin is one of the most active and abundant pigments in Pu-erh tea. Here, we show that theabrow...
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Article
Open AccessBile acid is a significant host factor sha** the gut microbiome of diet-induced obese mice
Intestinal bacteria are known to regulate bile acid (BA) homeostasis via intestinal biotransformation of BAs and stimulation of the expression of fibroblast growth factor 19 through intestinal nuclear farnesoi...
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Article
Open AccessHerbal medicine Yinchenhaotang protects against α-naphthylisothiocyanate-induced cholestasis in rats
Cholestasis is a clinical disorder defined as an impairment of bile flow, and that leads to toxic bile acid (BA) accumulation in hepatocytes. Here, we investigated the hepatoprotective effect of Yinchenhaotang...
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Article
Open AccessSex-dependent effects on gut microbiota regulate hepatic carcinogenic outcomes
Emerging evidence points to a strong association between sex and gut microbiota, bile acids (BAs), and gastrointestinal cancers. Here, we investigated the mechanistic link between microbiota and hepatocellular...
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Article
Open AccessThe Brain Metabolome of Male Rats across the Lifespan
Comprehensive and accurate characterization of brain metabolome is fundamental to brain science, but has been hindered by technical limitations. We profiled the brain metabolome in male Wistar rats at differen...
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Article
Open AccessBranched-chain and aromatic amino acid profiles and diabetes risk in Chinese populations
Recent studies revealed strong evidence that branched-chain and aromatic amino acids (BCAAs and AAAs) are closely associated with the risk of develo** type 2 diabetes in several Western countries. The aim of...
