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Article
Open AccessMulti-model analysis of gallbladder cancer reveals the role of OxLDL-absorbing neutrophils in promoting liver invasion
Gallbladder cancer (GBC) is the most common and lethal malignancy of the biliary tract that lacks effective therapy. In many GBC cases, infiltration into adjacent organs or distant metastasis happened long bef...
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Article
Enhanced homing of mesenchymal stem cells for in situ niche remodeling and bone regeneration
Mesenchymal stem cells (MSCs) transplantation is a promising strategy for osteoporosis treatment. However, limited sources and poor tissue-homing efficiency limit their clinical capabilities. In this study, we...
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Article
Pooling test statistics across multiply imputed datasets for nonnormal items
In structural equation modeling, when multiple imputation is used for handling missing data, model fit evaluation involves pooling likelihood-ratio test statistics across imputations. Under the normality assum...
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Article
Dealing with missing data in multi-informant studies: A comparison of approaches
Multi-informant studies are popular in social and behavioral science. However, their data analyses are challenging because data from different informants carry both shared and unique information and are often ...
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Article
Open AccessA postpartum functional assessment tool for women based on the international classification of functioning, disability and health
Postpartum dysfunctions and complications can occur in women. However, functional assessment should be conducted to make treatment plans before any intervention is implemented. In this context, the Internation...
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Article
Low-light Image Enhancement via Dual Reflectance Estimation
Improving the quality of low-light images is a fundamental task with vast applications in computer vision. Retinex-based methods which decompose the images into reflectance and illumination components have bee...
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Article
Assembly of peptide nanostructures with controllable sizes
Controlled peptide assembly offers significant promise to develop synthetic supramolecular nanostructures to display material and biological properties that mimic protein assemblies in nature. Despite the prog...
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Article
Daily walking kinematic characteristics of the elderly in different residential settings: experimental study on Chinese community-living elderly and long-term nursing home residents
Long-term nursing home (NH) care helps NH residents with their daily activities and improves their quality of life, but negatively affects their independent physical activities and increases the risk of danger...
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Article
A comparison of multiple imputation strategies to deal with missing nonnormal data in structural equation modeling
Missing data and nonnormality are two common factors that can affect analysis results from structural equation modeling (SEM). The current study aims to address a challenging situation in which the two factors...
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Article
Pre-pregnancy body mass index and gut microbiota of mothers and children 5 years postpartum
Maternal pre-pregnancy body mass index (BMI) has been linked to altered gut microbiota in women shortly after delivery and in their offspring in the first few years of life. But little is known about how long ...
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Article
Open AccessIncreased occurrences of consecutive La Niña events under global warming
Most El Niño events occur sporadically and peak in a single winter1–3, whereas La Niña tends to develop after an El Niño and last for two years or longer4–7. Relative to single-year La Niña, consecutive La Niña f...
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Book Review
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Article
Anthropogenic impacts on twentieth-century ENSO variability changes
El Niño/Southern Oscillation (ENSO) sea surface temperature (SST) variability increased after 1960, influenced by more frequent strong El Niño and La Niña events. Whether such changes are linked to anthropogen...
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Article
Open AccessAntarctic shelf ocean warming and sea ice melt affected by projected El Niño changes
Antarctic shelf ocean warming affects melt of ice shelf/sheets and sea ice but projected changes vary vastly across climate models. A projected increase in El Niño variability has been found to slow future mid...
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Article
Domain-specific feature elimination: multi-source domain adaptation for image classification
Multi-source domain adaptation utilizes multiple source domains to learn the knowledge and transfers it to an unlabeled target domain. To address the problem, most of the existing methods aim to minimize the d...
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Article
Viral Tools for Neural Circuit Tracing
Neural circuits provide an anatomical basis for functional networks. Therefore, dissecting the structure of neural circuits is essential to understanding how the brain works. Recombinant neurotropic viruses ar...
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Article
An ROS-Responsive Antioxidative Macromolecular Prodrug of Caffeate for Uveitis Treatment
Uveitis is a sophisticated syndrome showing a high relevance with reactive oxygen species (ROS). Herein, an ROS-responsive PEGylated polypeptide based macromolecular prodrug of herbaceous antioxidant ethyl caf...
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Article
Suppressed Atlantic Niño/Niña variability under greenhouse warming
The Atlantic Niño/Niña is a dominant mode of interannual variability peaking in boreal summer with substantial climate impacts. How the Atlantic Niño/Niña sea surface temperature (SST) variability may change u...
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Article
Open AccessBoosting nutrient starvation-dominated cancer therapy through curcumin-augmented mitochondrial Ca2+ overload and obatoclax-mediated autophagy inhibition as supported by a novel nano-modulator GO-Alg@CaP/CO
By hindering energy supply pathway for cancer cells, an alternative therapeutic strategy modality is put forward: tumor starvation therapy. And yet only in this blockade of glucose supply which is far from eno...
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Article
Enhanced North Pacific impact on El Niño/Southern Oscillation under greenhouse warming
A majority of El Niño/Southern Oscillation (ENSO) events are preceded by the North Pacific Meridional Mode (NPMM), a dominant coupled ocean–atmospheric mode of variability. How the precursory NPMM forcing on E...
