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Open AccessPrimary Ewing’s sarcoma of the uterine cervix: a case report and review of the literature
Ewing’s sarcoma (ES) is an aggressive cancer of bone and soft tissue, most of which tend to occur in the bone. Extraosseous Ewing’s sarcoma (EES) of the cervix is extremely rare.
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Open AccessAuthor Correction: FAR591 promotes the pathogenesis and progression of SONFH by regulating Fos expression to mediate the apoptosis of bone microvascular endothelial cells
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Open AccessPharmaceutical treatment status of patients with COPD in the community based on medical Internet of Things: a real-world study
This study aimed to investigate the real-world standardisation and adherence of medical treatment regimens in patients with chronic obstructive pulmonary disease (COPD) in the community for making future manag...
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Open AccessManagement of renal sinus angiomyolipoma: modified robotic nephron-sparing surgery in a single center
Renal sinus angiomyolipoma (RSAML) is a rare and typically complex renal tumor. The objective is to present our single-center experience with a modified technique of robotic nephron-sparing surgery (NSS) for t...
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Open AccessKIF22 promotes multiple myeloma progression by regulating the CDC25C/CDK1/cyclinB1 pathway
Multiple myeloma (MM) is an incurable hematological malignancy characterized by clonal proliferation of malignant plasma B cells in bone marrow, and its pathogenesis remains unknown. The aim of this study was ...
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Open AccessAnlotinib inhibits growth of human esophageal cancer TE-1 cells by negative regulating PI3K/Akt signaling pathway
Anlotinib is effective in treatment of many kinds of malignant cancer, but its antineoplastic effects on esophageal cancer remains unclear. This study aims to investigate its impact on esophageal cancer and th...
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Open AccessIdentification roles of NFE2L3 in digestive system cancers
Morbidity and mortality rates of Digestive System Cancers (DSC) continue to pose human lives and health. Nuclear factor erythroid 2-like protein 3 (NFE2L3) is aberrantly expressed in DSC. This study aimed to e...
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Open AccessPan-cancer analysis of DDIT4 identifying its prognostic value and function in acute myeloid leukemia
Acute myeloid leukemia (AML) is a hematological malignancy derived from the accumulation of abnormal proliferation of infantile leukocytes in the hematopoietic system. DNA-damage-inducible transcript 4 (DDIT4) ac...
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Open AccessCeramides and pro-inflammatory cytokines for the prediction of acute coronary syndrome: a multi-marker approach
There is a growing body of evidence supporting the significant involvement of both ceramides and pro-inflammatory cytokines in the occurrence and progression of acute coronary syndrome (ACS).
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Open AccessActivation of ETAR and ETBR in myocardial tissue characterizes heart failure induced by experimental autoimmune myocarditis
Endothelial dysfunction is characterized by an imbalance between endothelium-derived vasodilatory and vasoconstrictive effects and may play an important role in the development of heart failure. An increasing ...
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Open AccessA Multicenter, Randomized, Double-Blind, Placebo-Controlled, and Dose-Increasing Study on the Safety, Tolerability and PK/PD of Multiple Doses of HSK7653 by Oral Administration in Patients with Type 2 Diabetes Mellitus in China
This study assessed the safety, tolerability, and PK/PD of HSK7653 tablets in Chinese patients with type 2 diabetes mellitus (T2DM).
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Open AccessMonocyte to high-density lipoprotein cholesterol ratio predicts poor outcomes in ischaemic heart failure patients combined with diabetes: a retrospective study
The prevalence of ischaemic heart failure (HF) continues to increase. Diabetes mellitus (DM) concomitant with ischaemic HF increases the risk of major adverse cardiovascular events (MACEs). As a promising pred...
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Open AccessSingle-cell transcriptomic analysis reveals a systemic immune dysregulation in COVID-19-associated pediatric encephalopathy
Unraveling the molecular mechanisms for COVID-19-associated encephalopathy and its immunopathology is crucial for develo** effective treatments. Here, we utilized single-cell transcriptomic analysis and inte...
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Open AccessBreast-conserving surgery is an appropriate procedure for centrally located breast cancer: a population-based retrospective cohort study
The evidence of breast-conserving therapy (BCT) applied in centrally located breast cancer (CLBC) is absent. This study aims to investigate the long-term survival of breast-conserving therapy (BCT) in centrall...
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Open Access“Liu-Liang-Chung” syndrome with multiple congenital anomalies and the distinctive craniofacial features caused by dominant ZEB2 gene gain mutation
Contiguous gene gain syndrome including entire ZEB2 may be a novel syndrome. In the past, there were no easily distinct and recognizable features as a guide for precise clinical and genetic diagnosis of the syndr...
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Open AccessSupine transfer test-induced changes in cardiac index predict fluid responsiveness in patients without intra-abdominal hypertension
The reversible maneuver that mimics the fluid challenge is a widely used test for evaluating volume responsiveness. However, passive leg raising (PLR) does have certain limitations. The aim of the study is to ...
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Open AccessGold nanoparticles combat enveloped RNA virus by affecting organelle dynamics
Enveloped RNA viruses are a group of viruses with an outer membrane derived from a host cell and a genome consisting of ribonucleic acid (RNA). These viruses rely on host cell machinery and organelles to repli...
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Open AccessCharacterization of immunomodulatory factors and cells in bronchoalveolar lavage fluid for immune checkpoint inhibitor-related pneumonitis
As immune checkpoint inhibitors (ICIs) are widely used, a series of immune-related adverse events (irAEs) have been reported, including immune checkpoint inhibitor-related pneumonitis (ICI-pneumonitis). The in...
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Open AccessIdentification of crucial genes related to heart failure based on GEO database
The molecular biological mechanisms underlying heart failure (HF) remain poorly understood. Therefore, it is imperative to use innovative approaches, such as high-throughput sequencing and artificial intellige...
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Open AccessIncidence and risk factors of postoperative hyperamylasemia and pancreatitis following total knee arthroplasty: a retrospective study
Postoperative hyperamylasemia and pancreatitis are recognized complications after abdominal and spinal surgeries. The aim of this study is to investigate the incidence and identify risk factors for postoperati...