22 Result(s)

Article

Primary Ewing’s sarcoma of the uterine cervix: a case report and review of the literature

Ewing’s sarcoma (ES) is an aggressive cancer of bone and soft tissue, most of which tend to occur in the bone. Extraosseous Ewing’s sarcoma (EES) of the cervix is extremely rare.

Yuhang **ao, Yong Zhi, Guangxu Cao… in Journal of Cancer Research and Clinical On… (2024)

Article

KIF22 promotes multiple myeloma progression by regulating the CDC25C/CDK1/cyclinB1 pathway

Multiple myeloma (MM) is an incurable hematological malignancy characterized by clonal proliferation of malignant plasma B cells in bone marrow, and its pathogenesis remains unknown. The aim of this study was ...

Meng Zhai, Jiyu Miao, Ru Zhang, Rui Liu… in Journal of Cancer Research and Clinical On… (2024)

Article

Anlotinib inhibits growth of human esophageal cancer TE-1 cells by negative regulating PI3K/Akt signaling pathway

Anlotinib is effective in treatment of many kinds of malignant cancer, but its antineoplastic effects on esophageal cancer remains unclear. This study aims to investigate its impact on esophageal cancer and th...

Yueli Liu, Fan Li, Qiongyu Wang, Yunfei Zhang, Shuhong Tian, Biao Li in Discover Oncology (2024)

Article

Identification roles of NFE2L3 in digestive system cancers

Morbidity and mortality rates of Digestive System Cancers (DSC) continue to pose human lives and health. Nuclear factor erythroid 2-like protein 3 (NFE2L3) is aberrantly expressed in DSC. This study aimed to e...

Fan Li, Zhili Wen in Journal of Cancer Research and Clinical Oncology (2024)

Article

Pan-cancer analysis of DDIT4 identifying its prognostic value and function in acute myeloid leukemia

Acute myeloid leukemia (AML) is a hematological malignancy derived from the accumulation of abnormal proliferation of infantile leukocytes in the hematopoietic system. DNA-damage-inducible transcript 4 (DDIT4) ac...

Fangmei Li, Jiyu Miao, Rui Liu, Ru Zhang… in Journal of Cancer Research and Clinical On… (2024)

Article

Single-cell transcriptomic analysis reveals a systemic immune dysregulation in COVID-19-associated pediatric encephalopathy

Unraveling the molecular mechanisms for COVID-19-associated encephalopathy and its immunopathology is crucial for develo** effective treatments. Here, we utilized single-cell transcriptomic analysis and inte...

Yi Wang, Laurence Don Wai Luu, Shuang Liu… in Signal Transduction and Targeted Therapy (2023)

Article

Gold nanoparticles combat enveloped RNA virus by affecting organelle dynamics

Enveloped RNA viruses are a group of viruses with an outer membrane derived from a host cell and a genome consisting of ribonucleic acid (RNA). These viruses rely on host cell machinery and organelles to repli...

Fangzhou Li, Qianqian Huang, Ziran Zhou… in Signal Transduction and Targeted Therapy (2023)

Article

Characterization of immunomodulatory factors and cells in bronchoalveolar lavage fluid for immune checkpoint inhibitor-related pneumonitis

As immune checkpoint inhibitors (ICIs) are widely used, a series of immune-related adverse events (irAEs) have been reported, including immune checkpoint inhibitor-related pneumonitis (ICI-pneumonitis). The in...

Peng-Mei Wang, Zhong-Wei Zhang, Shan Zhang… in Journal of Cancer Research and Clinical On… (2023)

Article

Successful clearance of persistent SARS-CoV-2 asymptomatic infection following a single dose of Ad5-nCoV vaccine

Persistent asymptomatic (PA) SARS-CoV-2 infections have been identified. The immune responses in these patients are unclear, and the development of effective treatments for these patients is needed. Here, we r...

Shaofu Qiu, Zhao Chen, Airu Zhu, Qiuhui Zeng… in Signal Transduction and Targeted Therapy (2023)

Article

The toxic natural product tutin causes epileptic seizures in mice by activating calcineurin

Tutin, an established toxic natural product that causes epilepsy in rodents, is often used as a tool to develop animal model of acute epileptic seizures. However, the molecular target and toxic mechanism of tu...

Qing-Tong Han, Wan-Qi Yang, Caixia Zang… in Signal Transduction and Targeted Therapy (2023)

Article

First-in-human phase I study of CLL-1 CAR-T cells in adults with relapsed/refractory acute myeloid leukemia

Relapsed or refractory (R/R) acute myeloid leukemia (AML) has a poor prognosis. In this study, we evaluated chimeric antigen receptor (CAR) T cell therapy targeting CLL-1 in adults with R/R AML patients. Patie...

**n **, Meng Zhang, Rui Sun, Hairong Lyu, **a **ao… in Journal of Hematology & Oncology (2022)

Article

LncRNA-PACERR induces pro-tumour macrophages via interacting with miR-671-3p and m6A-reader IGF2BP2 in pancreatic ductal adenocarcinoma

LncRNA-PACERR plays critical role in the polarization of tissue-associated macrophages (TAMs). In this study, we found the function and molecular mechanism of PACERR in TAMs to regulate pancreatic ductal adeno...

Yihao Liu, Minmin Shi, **ngfeng He, Yizhi Cao… in Journal of Hematology & Oncology (2022)

Article

A potent human monoclonal antibody with pan-neutralizing activities directly dislocates S trimer of SARS-CoV-2 through binding both up and down forms of RBD

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic of novel coronavirus disease (COVID-19). The neutralizing monoclonal antibodies (mAbs) targeting the receptor-bindi...

**aofei Wang, Ao Hu, **angyu Chen, Yixin Zhang… in Signal Transduction and Targeted Therapy (2022)

Article

COVID-19 induces new-onset insulin resistance and lipid metabolic dysregulation via regulation of secreted metabolic factors

Abnormal glucose and lipid metabolism in COVID-19 patients were recently reported with unclear mechanism. In this study, we retrospectively investigated a cohort of COVID-19 patients without pre-existing metab...

** He, Chenshu Liu, Jiangyun Peng, Zilun Li… in Signal Transduction and Targeted Therapy (2021)

Article

Multi-platform omics analysis reveals molecular signature for COVID-19 pathogenesis, prognosis and drug target discovery

Disease progression prediction and therapeutic drug target discovery for Coronavirus disease 2019 (COVID-19) are particularly important, as there is still no effective strategy for severe COVID-19 patient trea...

Yuming Li, Guixue Hou, Haibo Zhou, Yanqun Wang… in Signal Transduction and Targeted Therapy (2021)

Article

Longitudinal dynamics of antibody responses in recovered COVID-19 patients

Meng-Li Cheng, Hui-Ying Liu, Hui Zhao… in Signal Transduction and Targeted Therapy (2021)

Article

Clinical utility of FDG PET/CT for primary and recurrent papillary renal cell carcinoma

Papillary renal cell carcinoma (RCC) is the second most common subtype of RCC, after clear cell RCC. This study aimed to investigate the usefulness of FDG PET/CT in primary and recurrent papillary RCC, and the...

Guozhu Hou, Dachun Zhao, Yuanyuan Jiang, Zhaohui Zhu, Li Huo, Fang Li… in Cancer Imaging (2021)

Article

Cathepsin L promotes angiogenesis by regulating the CDP/Cux/VEGF-D pathway in human gastric cancer

Increasing evidence indicates that angiogenesis plays an important role in tumor progression. The function of cathepsin L (CTSL), an endosomal proteolytic enzyme, in promoting tumor metastasis is well recogniz...

Tao Pan, Zhijian **, Zhenjia Yu, **ongyan Wu, **nyu Chang, Zhiyuan Fan… in Gastric Cancer (2020)

Article

Immune dysfunction leads to mortality and organ injury in patients with COVID-19 in China: insights from ERS-COVID-19 study

Dongze Li, You Chen, Hong Liu, Yu Jia… in Signal Transduction and Targeted Therapy (2020)

Article

Utility of diffusion weighted imaging with the quantitative apparent diffusion coefficient in diagnosing residual or recurrent hepatocellular carcinoma after transarterial chemoembolization: a meta-analysis

Accurate and early diagnosis of residual tumors or intrahepatic recurrences after TACE is critically needed for determining the success of treatments and for guiding subsequent therapeutic planning. This meta-...

Zhao Liu, **-Ming Fan, Chen He, Zhi-Fan Li, Yong-Sheng Xu, Zhao Li… in Cancer Imaging (2020)