-
Article
Open AccessAn integrated organoid omics map extends modeling potential of kidney disease
Kidney organoids are a promising model to study kidney disease, but their use is constrained by limited knowledge of their functional protein expression profile. Here, we define the organoid proteome and trans...
-
Article
Open AccessMolecular consequences of SARS-CoV-2 liver tropism
Extrapulmonary manifestations of COVID-19 have gained attention due to their links to clinical outcomes and their potential long-term sequelae1. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) displa...
-
Article
Open AccessMultiorgan tropism of SARS-CoV-2 lineage B.1.1.7
Due to the development of novel functionalities, distinct SARS-CoV-2 variants such as B.1.1.7 fuel the current pandemic. B.1.1.7 is not only more transmissible, but may also cause an increased mortality compar...
-
Article
Open AccessKidney organoid systems for studies of immune-mediated kidney diseases: challenges and opportunities
Acute and chronic kidney diseases are major contributors to morbidity and mortality in the global population. Many nephropathies are considered to be immune-mediated with dysregulated immune responses playing ...
-
Article
Open AccessImmune-mediated entities of (primary) focal segmental glomerulosclerosis
Focal segmental glomerulosclerosis (FSGS) represents a glomerular scar formation downstream of various different mechanisms leading to podocytopathy and podocyte loss. Recently, significant advances were made ...
-
Article
Open AccessNon-invasive pulmonary artery pressure estimation by electrical impedance tomography in a controlled hypoxemia study in healthy subjects
Pulmonary hypertension is a hemodynamic disorder defined by an abnormal elevation of pulmonary artery pressure (PAP). Current options for measuring PAP are limited in clinical practice. The aim of this study w...
-
Article
Noninvasive measurement of stroke volume changes in critically ill patients by means of electrical impedance tomography
Previous animal experiments have suggested that electrical impedance tomography (EIT) has the ability to noninvasively track changes in cardiac stroke volume (SV). The present study intended to reproduce these...
-
Article
Open AccessThe tetraspanin CD9 controls migration and proliferation of parietal epithelial cells and glomerular disease progression
The mechanisms driving the development of extracapillary lesions in focal segmental glomerulosclerosis (FSGS) and crescentic glomerulonephritis (CGN) remain poorly understood. A key question is how parietal ep...
-
Chapter
Pulse Wave Analysis Techniques
Pulse wave analysis, or PWA, is a technique based on the morphological analysis of blood pressure waveforms, whose shape reflects crucial information on the properties of the arterial wall and blood pressure i...
-
Article
Open AccessUrine-derived cells: a promising diagnostic tool in Fabry disease patients
Fabry disease is a lysosomal storage disorder resulting from impaired alpha-galactosidase A (α-Gal A) enzyme activity due to mutations in the GLA gene. Currently, powerful diagnostic tools and in vivo research mo...
-
Chapter and Conference Paper
Contactless Respiration Monitoring in Real-Time via a Video Camera
Until today, vital signs monitoring in neonatal intensive care units (NICUs) is based on wired sensors, known to cause discomfort and false alarms. In view of overcoming such issues we investigate a contactles...
-
Chapter and Conference Paper
Performance of Systolic Blood Pressure estimation from radial Pulse Arrival Time (PAT) in anesthetized patients
The performance of estimating Systolic Blood Pressure (SBP) in anesthetized patients via Pulse Arrival Time (PAT) techniques was studied with respect to the minimum required time in between two recalibration p...
-
Article
Noninvasive pulmonary artery pressure monitoring by EIT: a model-based feasibility study
Current monitoring modalities for patients with pulmonary hypertension (PH) are limited to invasive solutions. A novel approach for the noninvasive and unsupervised monitoring of pulmonary artery pressure (PAP...
-
Chapter and Conference Paper
Improving Card Fraud Detection Through Suspicious Pattern Discovery
We propose a new approach to detect credit card fraud based on suspicious payment patterns. According to our hypothesis fraudsters use stolen credit card data at specific, recurring sets of shops. We exploit t...
-
Chapter and Conference Paper
A graph-based, semi-supervised, credit card fraud detection system
Global card fraud losses amounted to 16.31 Billion US dollars in 2014 [18]. To recover this huge amount, automated Fraud Detection Systems (FDS) are used to deny a transaction before it is granted. In this pap...
-
Article
Open AccessTranscriptional profiling reveals progeroid Ercc1 -/Δ mice as a model system for glomerular aging
Aging-related kidney diseases are a major health concern. Currently, models to study renal aging are lacking. Due to a reduced life-span progeroid models hold the promise to facilitate aging studies and allow ...
-
Chapter
Von Heuschrecken und spätrömischer Dekadenz: Strategien im Kampf um Aufmerksamkeit
Politik braucht Öffentlichkeit. Egal ob Talkrunde, Parlamentsdebatte, Regionalkonferenz oder Bürgersprechstunde: Politik ist in demokratischen Gesellschaften immer auch ein Akt der öffentlichen Auseinandersetz...
-
Chapter and Conference Paper
Fixed-N superconductivity: The crossover from the bulk to the few-electron limit
We use two truly canonical approaches to describe superconductivity in ultrasmall metallic grains: (a) a variational fixed-N projected BCS-like theory and (b) the exact solution of the model Hamiltonian. Thereby ...
