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Chapter and Conference Paper
Pentoxifyllin als adjuvante Therapie der Multiorgandysfunktion
Die Sterblichkeit durch die Dysfunktion multipler Organe bzw. die Sepsis, die zur Organdysfunktion führt, ist trotz aller Fortschritte der intensivmedizinischen Therapie mit einer Letalität von 50 bis 70% unve...
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Article
Pentoxifylline in severe sepsis: a double-blind, randomized placebo-controlled study
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Article
Endotoxin inhibits heat shock protein 70 (HSP70) expression in peripheral blood mononuclear cells of patients with severe sepsis
Objective: To investigate the ex vivo endotoxin-inducible heat shock protein 70 (HSP70) expression in the peripheral blood mononuclear cells (PBMC) of patients with severe sepsis in orde...
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Chapter and Conference Paper
Modes of Ventilation and Weaning Strategies
The traditional mechanically ventilatory management of patients with acute lung injury has been based on the perception of a uniformly distributed lung damage. Conventionally, full ventilatory support has been...
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Article
Procalcitonin as a marker of severity in septic shock
Background/aims: Procalcitonin (PCT) was shown to be related to the severity of bacterial infection and is recommended as a new parameter of inflammation and infection. To evaluate the prognostic value in septic...
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Article
Vorteile der assistierten Spontanatmung
Spontaneous breathing with Biphasic Positive Airway Pressure (BIPAP) or Airway Pressure Release Ventilation (APRV) caused a reduction in intrapulmonary shunting and dead space ventilation and improvement in a...
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Article
Sex dimorphism and sepsis: a novel approach
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Article
Pilot Study Assessing TNF Gene Polymorphism as a Prognostic Marker for Disease Progression in Neonates with Sepsis
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Article
The PstI polymorphism of the endotoxin-inducible heat-shock protein 70–2 gene does not affect messenger RNA level in human whole-blood cultures
Objective: To determine whether the human leukocyte antigen linked biallelic heat-shock protein 70–2 (HSP70–2) gene polymorphism is associated with variable HSP70–2 messenger RNA express...
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Article
The common functional C(−159)T polymorphism within the promoter region of the lipopolysaccharide receptor CD14 is not associated with sepsis development or mortality
Sepsis is characterised by a systemic inflammatory response to bacterial products during infection, which interestingly both in humans and animal models is gender associated with a higher susceptibility of mal...
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Chapter and Conference Paper
Ventilator-Associated Systemic Inflammation
Positive pressure ventilation is commonly applied in patients undergoing general anesthesia or requiring ventilatory support due to acute respiratory failure to assure adequate ventilation and gas exchange. Co...
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Article
Increased susceptibility to apoptosis in circulating lymphocytes of critically ill patients
Background and aims: Lymphocyte apoptosis may influence immune responsiveness in systemic inflammation. Therefore, we investigated whether early signs of apoptosis (i.e., annexin-V bindi...
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Article
The influence of endotoxin on the expression of the ORL-1 receptor
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Article
Somatotropic axis dysfunction in critically ill patients: altered response to growth hormone-releasing hormone
Wachstumshormon (GH) hat neben anabolen Wirkungen auch immunmodulatorische Effekte. Der Einfluss von Wachstumshormon auf das Immunsystem wird kontrovers diskutiert. In der vorliegenden Studie wird die Funktio...
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Article
Protective functions of intracellular heat-shock protein (HSP) 70-expression in patients with severe sepsis
Intracellular expression of heat-shock-protein 70 (HSP70) arose early in evolutionary development as a tool to protect cellular homeostasis. HSP70 detects proteins that are incorrectly folded or denatured. Th...
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Article
Postoperative Schmerztherapie in Deutschland Ergebnisse einer Umfrage
Fragestellung. In einer Umfrage sollte eine Bestandsaufnahme zur Praxis der postoperativen Schmerztherapie in Deutschland erfolgen.
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Article
Kinetic and reversibility of mechanical ventilation-associated pulmonary and systemic inflammatory response in patients with acute lung injury
Objective. To investigate the kinetic and reversibility of mechanical ventilation-associated pulmonary and systemic inflammatory response in patients with acute lung injury (ALI).
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Article
Postoperative Analgesie mit Tramadol und Metamizol
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Article
Apoptose als Pathomechanismus in der Sepsis
Die Sepsis gehört nach wie vor zu den häufigsten Todesursachen bei Intensivpatienten. Der Pathogenese der Erkrankung liegt ein komplexes Immungeschehen zugrunde. Neueste Erkenntnisse zeigen, dass Zellen des Ab...
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Article
Livide Verfärbung der Hand als unerwünschtes Ereignis bei axillärer Plexusanästhesie
Im Rahmen der Durchführung einer axillären Plexusanästhesie zur Karpaltunnelspaltung kam es zur akzidentellen Punktion der A. axillaris. Im zeitlichen Zusammenhang damit trat eine livide Verfärbung der Hand au...