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Article
Gene expression profile alone is inadequate in predicting complete response in multiple myeloma
With advent of several treatment options in multiple myeloma (MM), a selection of effective regimen has become an important issue. Use of gene expression profile (GEP) is considered an important tool in predic...
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Article
Minor clone provides a reservoir for relapse in multiple myeloma
Recent studies have provided direct evidence for genetic variegation in subclones for various cancer types. However, little is known about subclonal evolutionary processes according to treatment and subsequent...
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Article
CD33 is expressed on plasma cells of a significant number of myeloma patients, and may represent a therapeutic target
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Article
Ploidy, as detected by fluorescence in situ hybridization, defines different subgroups in multiple myeloma
Ploidy appears as an important parameter in both the biology and the clinical evolution of multiple myeloma. However, its evaluation requires either a successful karyoty** (obtained in 30% of the patients) o...
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Article
Genetic heterogeneity in multiple myeloma
In the past decade, many progresses have been made in our knowledge of the genetics of multiple myeloma. The use of molecular cytogenetic techniques has led to the identification of several recurrent (cyto)gen...