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  1. Article

    Open Access

    Targeting pyruvate dehydrogenase kinase 1 overcomes EGFR C797S mutation-driven osimertinib resistance in non-small cell lung cancer

    Osimertinib, a selective third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), effectively targets the EGFR T790M mutant in non-small cell lung cancer (NSCLC). However, the new...

    Wonyoung Park, Shibo Wei, Chu-Long **e, Jung Ho Han… in Experimental & Molecular Medicine (2024)

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  2. No Access

    Article

    Cellular and subcellular localization of endogenous phospholipase D6 in seminiferous tubules of mouse testes

    Phospholipase D6 (PLD6) plays pivotal roles in mitochondrial dynamics and spermatogenesis, but the cellular and subcellular localization of endogenous PLD6 in testis germ cells is poorly defined. We examined t...

    Tae-Ryong Riew, Soo** Kim, Xuyan **, Hong Lim Kim… in Cell and Tissue Research (2021)

  3. No Access

    Article

    Ultrastructure and synaptic connectivity of main and accessory olfactory bulb efferent projections terminating in the rat anterior piriform cortex and medial amygdala

    Neurons in the main olfactory bulb relay peripheral odorant signals to the anterior piriform cortex (aPir), whereas neurons of the accessory olfactory bulb relay pheromone signals to the medial amygdala (MeA),...

    Sook Kyung Park, Jong Ho Kim, Eun Sun Yang, Dong Kuk Ahn… in Brain Structure and Function (2014)

  4. No Access

    Article

    Silencing of cytosolic NADP+-dependent isocitrate dehydrogenase gene enhances ethanol-induced toxicity in HepG2 cells

    It has been shown that acute and chronic alcohol administrations increase the production of reactive oxygen species, lower cellular antioxidant levels and enhance oxidative stress in many tissues. We recently ...

    Eun Sun Yang, Su-Min Lee, Jeen-Woo Park in Archives of Pharmacal Research (2010)

  5. No Access

    Article

    The coffee diterpene kahweol induces apoptosis in human leukemia U937 cells through down-regulation of Akt phosphorylation and activation of JNK

    Kahweol, the coffee-specific diterpene, has been reported for its tumor cell growth inhibitory activity and anti-carcinogenic activity. The mechanism by which kahweol initiates apoptosis remains poorly underst...

    Jung Hwa Oh, Jung Tae Lee, Eun Sun Yang, Jong-Soo Chang, Dong Sun Lee… in Apoptosis (2009)

  6. No Access

    Article

    Epigallocatechin gallate, a constituent of green tea, regulates high glucose-induced apoptosis

    A high concentration of glucose has been implicated as a causal factor in initiation and progression of diabetic complications, and there is evidence to suggest that hyperglycemia increases the production of f...

    Chang Joo Oh, Eun Sun Yang, Seoung Woo Shin… in Archives of Pharmacal Research (2008)

  7. No Access

    Article

    Antioxidant enzyme inhibitors enhance peroxynitrite-induced cell death in U937 cells

    Peroxynitrite, a potent physiological inorganic toxin, is known to play a critical role in cellular oxidative damage. The protective role of antioxidant enzymes against peroxynitrite-induced oxidative damage i...

    Eun Sun Yang, Jeen-Woo Park in Molecular and Cellular Biochemistry (2007)

  8. No Access

    Article

    Protection of peroxynitrite-induced DNA damage by dietary antioxidants

    The present study was undertaken to test the hypothesis that dietary antioxidants protect DNA damage induced by peroxynitrite, a potent physiological inorganic toxin. The present study showed that dietary anti...

    Hye Kyung Moon, Eun Sun Yang, Jeen Woo Park in Archives of Pharmacal Research (2006)