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Article
A dietary commensal microbe enhances antitumor immunity by activating tumor macrophages to sequester iron
Innate immune cells generate a multifaceted antitumor immune response, including the conservation of essential nutrients such as iron. These cells can be modulated by commensal bacteria; however, identifying a...
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Article
Open AccessBaf-mediated transcriptional regulation of teashirt is essential for the development of neural progenitor cell lineages
Accumulating evidence hints heterochromatin anchoring to the inner nuclear membrane as an upstream regulatory process of gene expression. Given that the formation of neural progenitor cell lineages and the sub...
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Article
Open AccessUnique adipose tissue invariant natural killer T cell subpopulations control adipocyte turnover in mice
Adipose tissue invariant natural killer T (iNKT) cells are a crucial cell type for adipose tissue homeostasis in obese animals. However, heterogeneity of adipose iNKT cells and their function in adipocyte turn...
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Article
Open AccessCompositional changes in fecal microbiota in a new Parkinson's disease model: C57BL/6-Tg(NSE-haSyn) mice
The gut–brain axis (GBA) in Parkinson's disease (PD) has only been investigated in limited mice models despite dysbiosis of the gut microbiota being considered one of the major treatment targets for neurodegen...
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Article
Open AccessChemosensitivity to doxorubicin in primary cells derived from tumor of FVB/N-Trp53tm1Hw1 with TALEN-mediated Trp53 mutant gene
To evaluate the chemosensitivity to doxorubicin (DOX) in two primary cells derived from a tumor of FVB/N-Trp53tm1Hw1 knockout (KO) mice with TALEN-mediated Trp53 mutant gene, we evaluated the cell survivability, ...
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Article
Impaired BCAA catabolism in adipose tissues promotes age-associated metabolic derangement
Adipose tissues are central in controlling metabolic homeostasis and failure in their preservation is associated with age-related metabolic disorders. The exact role of mature adipocytes in this phenomenon rem...
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Article
Open AccessGossypetin ameliorates 5xFAD spatial learning and memory through enhanced phagocytosis against Aβ
Microglia are the resident immune cells found in our brain. They have a critical role in brain maintenance. Microglia constantly scavenge various waste materials in the brain including damaged or apoptotic neu...
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Article
Open AccessMelanin biopolymer synthesis using a new melanogenic strain of Flavobacterium kingsejongi and a recombinant strain of Escherichia coli expressing 4-hydroxyphenylpyruvate dioxygenase from F. kingsejongi
Melanins are a heterologous group of biopolymeric pigments synthesized by diverse prokaryotes and eukaryotes and are widely utilized as bioactive materials and functional polymers in the biotechnology industry...
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Article
Open AccessHomeostatic serum IgE is secreted by plasma cells in the thymus and enhances mast cell survival
Increased serum levels of immunoglobulin E (IgE) is a risk factor for various diseases, including allergy and anaphylaxis. However, the source and ontogeny of B cells producing IgE under steady state condition...
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Article
Open AccessSingle-cell RNA sequencing identifies shared differentiation paths of mouse thymic innate T cells
Invariant natural killer T (iNKT), mucosal-associated invariant T (MAIT), and γδ T cells are innate T cells that acquire memory phenotype in the thymus and share similar biological characteristics. However, ho...
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Article
Trainees’ adenoma detection rate is higher if ≥10 minutes is spent on withdrawal during colonoscopy
It has been demonstrated that prolonged colonoscopic withdrawal times (WT; >6 min) are beneficial for the adenoma detection rate (ADR) for experienced endoscopists. There are little data, however, to guide the...
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Article
Formation of reversed austenite during tempering of 14Cr−7Ni−0.3Nb−0.7Mo−0.03C super martensitic stainless steel
Reversed austenite transformation and existence of retained austenite during tempering of the super martensitic stainless steel of Fe-14Cr-7Ni-0.3Nb-0.7Mo-0.03C were studied by means of experiments on microstr...
